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Our new preprint (the very first one in my life ;) is here with Ahmed Ashour Ahmed Christopher Yau Ahmed Lab

Tight junction protein ZO-1 is our #CellLine of the week 🧫 Our #CRISPR gene-edited fluorescently-tagged human iPS cell lines illuminate key structures in human cells. These lines are openly available through our Allen Cell Collection via allencell.org.

This time we aim to go beyond individual chromosomes but really have an integrated picture of the diploid genome structure in the entire nucleus. Also a terrific working experience with Alejandro Reyes, Sarah, Martin, Brad and Bin Zhang!

I'm so happy our paper get online today! I'm espeically pround of making this work into a real resource. We have made the data and source code entirely available to the community. Genome-Scale Imaging of the 3D Organization and Transcriptional Activi... sciencedirect.com/science/articl…

Resource in this issue of Cell: Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin - zpr.io/Hjvby

Congratulations to my wonderful graduate student Dr Jinghui Liu MIT Physics who successfully defended her PhD thesis on 'Topology, Symmetry & Mechanics: Deciphering and Controlling information flows in a living cell'. Her next stop: Center for Systems Biology Dresden calendar.mit.edu/event/physics_…

Thrilled to see our work finally online! We utilized in situ spatial transcriptomic method STARmap PLUS to map 1.09 million cells in the adult mouse central nervous system at molecular resolution and identified previously unknown tissue architectures. nature.com/articles/s4158…

Cell-type-specific 3D-genome organization and transcription regulation in the brain biorxiv.org/cgi/content/sh… #bioRxiv

I'm glad last piece of my PhD work came out! What could MERFISH derived technologies could accomplish beyond this? Please follow my future work!

Very delighted to share our work Deciphering cell states and genealogies of human hematopoiesis online today in nature (Accelerated Preview version). It is a really great collaboration of Weissman lab Jonathan Weissman's Lab and Sankaran lab Vijay Sankaran doi.org/10.1038/s41586… 🧵(1/n)

Check out our preprint on Perturb-multi (doi.org/10.1101/2024.1…), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.

Great work extending MERFISH into bacteria! | Science science.org/doi/10.1126/sc…

Great work done with the amazing team! More exciting work TBD!