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Excited to announce the completion of the first adult brain connectome - FlyWire is the neuronal wiring diagram of a Drosophila melanogaster brain with >130K neurons and >32M synapses. Explore at codex.flywire.ai. Check out the preprints:

We're done! A historic milestone for neuroscience brought to you by the FlyWire Consortium. Don't take my word for it. See the glory of the fly brain for yourself at flywire.ai/gallery

4 years. 250 people. 2.7 million edits to proofread 127,000 neurons. The fly connectome is here! Preprint: Neuronal wiring diagram of an adult brain biorxiv.org/content/10.110… Explore it in Codex: codex.flywire.ai

Building the FlyWire #connectome from the FAFB brain was a massive team effort. But neuroscientists need to find their favourite neurons in this huge dataset. We report an indexed parts list, systematically annotating all 127k neurons (Schlegel et al biorxiv.org/content/10.110…) 1/7

Very exciting to see this monumental work out! We are humbled and proud for having contributed to this milestone in neuroscience with our cell shape proofreading service. Thanks a lot for this awesome opportunity Davi Bock and Greg Jefferis

The current wave of interest is a good time to also promote our recently updated paper on neurotransmitter prediction directly from EM (a task humans struggle with). This was used to add nts -> sign to the just released full brain Connectome. biorxiv.org/content/10.110…

The release of the first whole adult fly brain wiring diagram marks a turning point for neuroscience: end-to-end reconstruction of neuronal information processing from sensory input to motor output. Congratulations to the entire team!

We mapped the connections between high order sensory inputs and memory cells in the octopus brain, first-ever reconstructed octopus memory circuit: data and principles of circuit assembly today in eLife doi.org/10.7554/eLife.…, joint work w/ Flavie Bidel Hebrew University& Harvard University,RT!👇

We posted our pre-print today describing how the Connectome Annotation Versioning Engine (CCAVE) supports analyzing and editing the worlds largest connectomics datasets biorxiv.org/cgi/content/sh…! Sven Dorkenwald @csdashm Allen Institute Sebastian Seung!

Our paper with "Tony" Runzhe Yang describing the network statistics of the whole-brain connectome of a complete adult Drosophila brain is now available on BioRxiv! biorxiv.org/content/10.110… 1/6

What should we do? 🔹 Tax vehicles by weight. 🔹 Test vehicles for pedestrian and cyclist safety (still doesn’t happen in the US) 🔹 Require a CDL for the most gigantic vehicles Left alone, this problem will only worsen. Governments must step up. slate.com/business/2023/…

Papers reporting the fly whole-brain connectome were published in nature today 🎉 and it was my honor to write a News and Views about them Congrats to Sven Dorkenwald, Sebastian Seung, Murthy Lab, Greg Jefferis, and the FlyWire team! + great 🧵 below from David nature.com/articles/d4158…

Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today

"Big buzz! nature published ~a dozen papers on the most comprehensive map of neuronal connectivity to date, a connectome of a fruit fly brain! The FlyWire consortium includes UW_NBIO affiliate Forrest Collman and Shanahan Fellow Sven Dorkenwald (Sven Dorkenwald). FlyWire

Congrats on an epic achievement. What a long way we've come!

Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey