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1/🧵Excited to re-introduce Memento in (cell.com/cell/fulltext/…), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇

Congrats to our friends at the Broad Institute on the launch of Cell Annotation Service (CAS). CAS is a ML tool trained on over 87M+ cells from the CZ #CellxGene corpus to make identifying cell types and states in #scRNAseq studies more efficient

Ajax AjaxTherapeutics is now a clinical-stage company! First patient with myelofibrosis #MPNsm has been dosed w/ AJ1-11095, the 1st type II JAK2 inhibitor to reach clinical trials. "FPFV" is always such an exciting milestone. Grateful to patients & investigators. ajaxtherapeutics.com/ajax-therapeut…

Trying to wrap my head around these figures. Speechless isn’t the word.

Rashida Tlaib is doing GOTV in Michigan. The Uncommitted movement are up on the air with anti-Trump ads. These folks deserved so much better from the party. But in spite of it all, they know how much is at stake and they're throwing in to fight against the fascist movement.

I’m not a puppet Elon.. I’m a daughter of two immigrant parents that had to work their ass off to provide for me! I’m a product of welfare, I’m a product of section 8, I’m a product of poverty and I’m a product of what happens when the system is set up against you….But you don’t

Never ceases to amaze me how many folks who’ve heard RATM are in Paul Ryan mode, having literally ZERO understanding of anything that band was about and even less understanding where any of us might stand on contemporary issues. Recently was talking to a couple at a restaurant

I’m excited to share an R package that we’ve created for mapping scRNA-seq data across normal and malignant hematopoiesis! We've used this to identify hematopoietic stem cells from healthy tissues and map leukemia cells from hundreds of patients. 1/6 github.com/andygxzeng/Bon…

🧬 "Two subtle problems with over-representation analysis" highlights critical limitations in popular enrichment tools, e.g.: background reduction & false discovery rates. These challenges impact reliability of results in #RNAseq data analysis. doi.org/10.1093/bioadv…

I am very skeptical of the AI/ML/computational methods to predict protein-protein interactions. Prove me wrong. I present a challenge for anyone who claims they can predict protein-protein interactions. 1/n

Not that it matters with a GOP trifecta, but Puerto Rico just decisively voted for statehood *again* with an absolute majority in a three-option race. Puerto Rico has more people than 22 states, all of them are US citizens, and yet it's completely left out to dry.

1/ Introducing SCimilarity, a new foundation model to explore scRNAseq data across tissues and diseases! It learns a common measure of cell similarity by training a deep metric learning model on millions of cells from various human tissues and conditions. nature.com/articles/s4158…

Incredibly excited to see this brilliant work from Graham Heimberg #AvivRegev out this week. Years in the making, Graham thought of this before foundation models became cool :) A foundation model for searching & finding the closest cell state, and experimentally validated!

7 million pairs! A great resource for TCR-antigen interaction. TRAIT: A Comprehensive Database for T-cell Receptor-Antigen Interactions biorxiv.org/content/10.110…

Thrilled to share our review on evolution of #MPN from normal #HSC, co-authored with Hormoz Lab & Vijay Sankaran & out as early view Haematologica Hope its a good resource, we enjoyed putting to together, feedback welcome! #MPNsm Early View | Haematologica haematologica.org/article/view/1…

scRNA-seq data sets exploding in number and size - check out scanpy & anndata for >1b cells: new experimental update includes APIs for scaling with dask from anndata, integrated with lots of scanpy and rapids-singlecell functions. gist.github.com/ilan-gold/9880…

Excited to share the final chapter my PhD research on medRxiv! eQTLs only explain 30% of GWAS loci and 11% of trait heritability. Here we investigate if epigenetic QTL can provide new insights at the remaining GWAS loci. medrxiv.org/content/10.110…

Our GWAS meta-analysis on the genomic architecture of 40 circulating cytokines in 75,000 individuals is now out Communications Biology 🧬❗️ A short thread about the topline findings🧵

A month ago we Vevo Therapeutics announced that we have generated the largest single-cell perturbation atlas in history, Tahoe-100M. Today, we announce that we will fully open-source Tahoe-100M in Feb, as part of a collaboration with NVIDIA Healthcare to train cell state models.

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