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I am very happy to share our latest exciting results on the mechanism by which Oct4, a master regulator of stem cells, binds to DNA wrapped around histone proteins. Thanks to all co-authors, especially to Caitlin MacCarthy and Jan Huertas biorxiv.org/content/10.110…

After 6 months of work, I'm happy to share a much improved article with lots of new data further strengthening our conclusions. Its great to see the progress from preprint versions. Thanks especially to Caitlin M. MacCarthy and Jan Huertas for this effort. biorxiv.org/content/10.110…

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells. Fine collaboration of LeXiong Michael Lidschreiber @taras_velychko Livia Caizzi with Schöler lab. doi.org/10.7554/eLife.… eLife - the journal

The #GSCN2022 Conference & 20 years Stem Cells NRW has started! Great opening by Hans Schöler MPI Molecular Biomedicine and Fiona Doetsch. Looking forward to exciting 4 days. #stemcells @berlinnovation

A great kick off for the German Stem Cell Network Meeting 2022. MPI Molecular Biomedicine #nonPImeeting #GCSN2022

Nobel laureate Shinya Yamanaka giving a lecture at the 10th GSCN and 20 Years Stem Cells NRW meeting. What an honour that he came all the way from Japan! mkw.nrw MPI Molecular Biomedicine #GSCN2022

Honored to present our unpublished work on enhancing the Yamanaka cocktail to Shinya Yamanaka himself at #GSCN2022, and to win a poster prize 🥂 Thanks to Caitlin M. MacCarthy for her great contribution to the project and for capturing the moment :) GSCN

Ever wonder what transcription factors look like in action? Our study sheds light on the interplay between Oct4, histone tails, and nucleosomal DNA. Thanks Vlad Cojocaru Jan Huertas & all authors! #allyouratomsareshowing #multidomainsTFshavemorefun(ctions) doi.org/10.1093/nar/gk…

Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. elifesciences.org/inside-elife/5…

Congrats to Haoqing Hu who led a team to show why it needs SOX17 rather than SOX2 to generate pluripotent and multipotent stem cells with high efficiency and quality Nucleic Acids Res HKU Medicine academic.oup.com/nar/article/do…

Online Now! Highly cooperative chimeric super-SOX induces naive pluripotency across species dlvr.it/T0V194 #stemcells

Super thrilled to announce our latest breakthrough! Introducing gamechanger #supersox that enhances iPSC quality & generation from various species🐁🐖 🐄🐒👴🏼👵🏼 thnx Sergiy Velychko Caitlin M. MacCarthy Ralf Jauch george church Hans Scholer #StemCellResearch #breakthrough sciencedirect.com/science/articl…

1. In the beginning there was Sox, and the Sox was Sox2. A billion years later we created super-SOX: dlvr.it/T0V194 Merry SOXmas! 🚀🧦

And in the roundup: 1) A GENtoniK cocktail 🍸 Emiliano Hergenreder Lorenz Center for Stem Cell Biology at Sloan Kettering 2) Pancreatic organoids ♋️ Weill Cornell Medicine Surgery Cell Stem Cell 3) Mammary organoids 🧫 @NCIResearchCtr Developmental Cell 4) Chimeric super-SOX 🧦 Sergiy Velychko Caitlin M. MacCarthy

Our Matters Arising preprint highlights the following issues with the Transient Naive Treatment (TNT) method for improved generation of human iPSCs published nature : 1. Characterization of bulk iPSCs rather than clonal iPSC lines; 2. Persistent Sendai virus expression in most

But can it run a gel?

Proud to see this out now. We tried to give this topic a different perspective, put more weight on the MD simulations and NMR and look forward to the future that we believe should focus on dynamics. link.springer.com/article/10.100…

Excited about george church lab's latest paper at EMBO Reports, where I collaborated with mpsmela to combine super-SOX naïve reset with his new set of factors to improve production of human oogonia - advancing towards iPSC-derived in vitro egg generation 🥚👶