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Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).

I'm spending more time on the other social network these days, but it's still worth posting that we'll be at #cellbio24 #ASCB! If you like LIM proteins or septins come check out our posters:

Preprint alert: Ready-to-use supplemental foods save lives. Fascinating work by Zehra Jamil Aga Khan University Gabe Hanson Virginia BME and team reveals host-microbiome factors that predict degree + durability of response in childhood wasting Asad Ali MBBS, MPH AKU Community Health Sciences medrxiv.org/content/10.110…

Excited that the peer-reviewed version of our fascin structure paper is now out in NatureStructMolBiol. Thanks very much to the referees for their constructive feedback. rdcu.be/d6Tct

Happy #MicroscopyMonday! With Seham Ebrahim we’re capturing single-cell behavior deep in the mouse intestine—no lumen opening needed! Thanks to neutrophil-YFP mice from Dr. Arandjelovic at UVA, we imaged “tiny steps” of neutrophils across endothelial cells at just 30 ms exposure

Have cutting-edge cell biology research to share? Submit to Molecular Biology of the Cell (MBoC)- dedicated to advancing discovery and fostering collaboration. Proud to be part of the editorial team supporting groundbreaking science. molbiolcell.org #CellBiology #MBoC

#3DThursday with Seham Ebrahim Inside the gut: Villi = nutrient uptake + barrier + immune balance. 🔴 Phalloidin 🔵 DAPI 🟢 Clvd caspase-3 (apoptotic extrusion!) Fixed tissue, imaged in 3D — stunning, structural, and full of insight. #Microscopy #3DImaging #Biophysics

Have you ever wondered if liver zonation is conserved from mice to humans? And how does fibrosis affect zonation in patients? Now, these questions are answered using scDVP. Some collaborations are meant to be Caroline Weiss Florian Rosenberger Matthias Mann Lab MLSB

🧫 A gentle reminder that your gut is an actual work of art. #FluorescenceFriday #BeneathTheScope

The neurons beneath everyday sensations. "How does pressure and vibration across millions of nerve endings become a hug?" "Of all the senses, the somatosensory system is the most complex, and therefore touch, some researchers argue, is the most difficult to study." #Science

Happy #MicroscopyMonday! Bees didn’t invent the honeycomb—biology’s been doing it at the single-cell level all along. 🟢 GFP-tagged junctions 🔵 Hoechst-stained nuclei A living mouse intestinal villus. No blueprint. Just (bio)physics. #intravitalimaging #cellbiology #OME

From stem cell to structure- This human colonoid shows the self-organization of intestinal epithelial cells in 3D—nuclei in magenta, actin in green. A living miniature gut for your #FluorescenceFriday.

We know the #microbiome can influence the brain, but the brain can also influence the microbiome! #MedTwitter #GITwitter nature.com/articles/s4225…

Real-life Fourier series

"Stereocilia"- actin-based skyscrapers that adorn sensory cells of our inner ear and covert vibrations into electrical signals—the first step in hearing and balance. #FluorescenceFriday

New organelle uncovered by in situ #cryoET: the #hemifusome, a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do. rdcu.be/emtQu #CryoET #MembraneBiogenesis #Organelle 🧵1/5

Something new and fun to chew on for all #organelle, #MembraneFusion, #MembraneTrafficking, #CryoET enthusiasts!

A big thank you to the AACR TME working group for this feature on our work on Pancreatic Cancer!

Grateful to see a briefing of our new paper shared more widely always meaningful when the science resonates beyond the lab. Great collaboration with amazing scientists shiqiong hu Seham Ebrahim Bechara Kachar