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Listen to an interview with JAMA Cardiology authors @LuisRLopesDr and Senthil Selvaraj, MD, MS, MA on their recent articles hosted by @sday_hcm. Find the episode on AMA Ed Hub™. ja.ma/3yXFlai

Great study on TTR variants in #UKB @LuisRLopesDr jamanetwork.com/journals/jamac… Congrats Duke Cardiology Fellows 🌟Jessica Regan on leading excellent editorial in JAMA Cardiology & 🙏 Marianna Fontana for collaboration! jamanetwork.com/journals/jamac… Duke Heart Duke Heart Failure Duke MPI Duke Clinical and Translational Science Institute

#Metabolomics has the power to identify mechanisms of #HeartFailure & #cardiometabolic disease, & shows promise as biomarkers for #HF diagnosis, prognosis & response to therapy. Innovative approaches using metabolomic technologies will impact precision care for HF

Thanks Cornerstone Medical Education for the opportunity as well as chairs Ahmad Masri & team! Big 🙏 to fantastic collaborators scottdavidsolomon Svati Shah Robert Mentz, MD Michel Khouri Sadiya Khan Parag Goyal MD MSc marianna fontana Richardkcheng Duke Heart Manesh Patel Duke Heart Failure

Fun night gathering with the Duke Cardiology HF crew! Can’t beat a beautiful October evening in Durham. Great colleagues - amazing people Duke Clinical Research Institute Duke Heart Manesh Patel

We need to consider more systematic genetic screening for risk of hereditary cardiac amyloid & need more data to determine best approach. This has to be done collaboratively w/the community! Read fantastic perspective piece from Senthil Selvaraj, MD, MS, MA Jessica Regan & illustrious co-authors

Tremendous job Jessica Regan in leading this piece! 🙏 Svati Shah for terrific insights on framework, as well as stellar guidance from other dream team co-authors Michel Khouri Opeyemi Olabisi Kevin Alexander Sadiya Khan Journal of Cardiac Failure Duke Clinical and Translational Science Institute Duke Cardiology Fellows Duke Heart

Towards #Metabolomic-Based Precision Approaches for Classifying and Treating #HeartFailure Personalized approach to metabolomic phenotyping in HF jacc.org/doi/10.1016/j.… JACC Journals Svati Shah Kavita Sharma

Standing room only at the Kidney Connection to HFpEF session at #KidneyWk!! Extremely high rates of HFpEF in our patients, but as Rupal Mehta points out, we have limited data & aren’t looking for this enough Senthil Selvaraj, MD, MS, MA Hiddo Heerspink

Outstanding session Jordy Cohen, MD, MSCE! So much interest in this intersection and more to learn. Kudos to planning committee for fantastic talks. Hiddo Heerspink Rupal Mehta #KidneyWk American Society of Nephrology

Metabolic dysfunction: An important driver of incident heart failure with preserved and reduced ejection fraction onlinelibrary.wiley.com/doi/abs/10.100…

Our phase I study of 2 doses of exogenous ketones detailing PK and metabolic profiling in HFrEF by background SGLT2i Simpub #AHA24 & JACC Journals #JACCBTS jacc.org/doi/10.1016/j.… 🙏 Svati Shah Margulies Lab Robert Mentz, MD Marat Fudim, MD MHS and outstanding team Duke Heart Duke MPI

Metabolic and Pharmacokinetic Profiling of an Exogenous Ketone Ester by Background SGLT2 Inhibitor Therapy in HFREF Hemodynamic effects were transient and irrespective of KE dose or background SGLT2i use, though acidosis was dose-dependent jacc.org/doi/10.1016/j.…

✒️Congratulations to Senthil Selvaraj, MD, MS, MA and Svati Shah! Dr. Shah directs the Duke Center for Precision Health, and Dr. Selvaraj is a member of the center's leadership team. The center is a partnership with #DukeCTSI and DukePrecisionGenomics.

#Editorial - SGLT2 Inhibitors and Their Effect on Metabolism in Patients With Heart Failure ahajournals.org/doi/full/10.11…

Learn about the most effective interventions to achieve adequate suppression of physiologic myocardial FDG uptake before inflammation/inflammatory imaging. Senthil Selvaraj, MD, MS, MA @dukeheartcenter Paco E. Bravo, MD Penn Cardiology Read now👉bit.ly/3OwKOsM #CVNuc

Outstanding Duke Heart grand rounds with Dr. Sanjiv Shah from NM Cardiovascular on HFpEF management in the age of precision medicine! Sanjiv J. Shah, MD Manesh Patel Jennifer Rymer Adrian “WE NEED RCTS!” Hernandez Duke Clinical Research Institute Robert Mentz, MD Michael Felker Senthil Selvaraj, MD, MS, MA Mark Kittipibul MD Marat Fudim, MD MHS Steve Greene

In KETO-HFpEF, despite robust ketosis, shifting substrate utilization away from carbohydrates, & 📉 estimated LV filling pressures, acute KE supplementation did not improve peak VO2 or constant-intensity exercise in #HFpEF jacc.org/doi/10.1016/j.… #ACC25 #JACCHF Senthil Selvaraj, MD, MS, MA