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The 9th New England Cryo-EM Symposium will be hosted this year at Harvard Medical School on Nov 9th, 2022. We look forward to welcoming researchers from New England and beyond to Harvard Medical School! More details and registration: tinyurl.com/2xtyauzx

Meet the newest addition to the Vos lab Seychelle Vos MIT Biology . Still in training, and resting in preparation for the long weekend.

I am very humbled to have been selected as a Freeman Hrabowski Scholar. Big thanks to my lab, my postdoc and PhD mentors, and my fantastic colleagues at MIT. You all made this happen. #FHScholars #MITBiology hhmi.org/news/hhmi-name…

What does it take to degrade a protein? Turns out all you need is a C-terminal amide. In a great collaboration between Jacob Corn and Bode Group we identified C-terminal amides as a degron recognized by SCF/FBXO31. @matthias_muhar Raphael Hofmann

The proteasome is an FDA-approved target for cancer, but targeting its different sites has been limited until now. With a cue from nature, we designed a suite of inhibitors to complement current treatments like Velcade. Read my debut as a first author here tinyurl.com/y4wxzyab

The HHMI Freeman Hrabowski application process opened today. It is a fantastic program for supporting strong mentoring and research. It is a privilege to be part of this amazing program. You can learn more here: hhmi.org/programs/freem… #FHScholars

Congratulations to twitter less Bonnie Su on her first paper from the lab! Bonnie shows that NELF can bind Pol II in two distinct confrontations that support either pausing or elongation. She did this using actively transcribing complexes. Read it here: authors.elsevier.com/sd/article/S10…

So excited to be part of this fantastic team!

Proud of our labs contributions to this paper! Big shout out to postdoc TJ Russell and masters students Katha Schneider and Annika Brem.

#MSRPBio is my favorite program at MIT. I loved meeting with this year’s group on Monday. Thank you MandanaMSRP for organizing such a wonderful program and bringing great students to MIT for the summer every year!

Congratulations to Nika Fendler on her recent graduation and her work on MORC2! MORC2 is a GHKL ATPase involved in gene silencing. Nika identified how it binds DNA and showed that it can capture multiple DNAs. Read more about it here: biorxiv.org/content/10.110…

See Bonnie, a grad student in the Vos lab, talk about her work here!

Congratulations to graduate students @AMohamed_98 from our group and Peter Wang from the Bartel lab on determining the structure of human AGO2 in the slicing conformation. This was a challenging project with many exciting results. Read our preprint to learn more!

A childhood interest in the complex worlds within an organism that the naked eye cannot see ultimately led Praise Lasekan to the BSG-MSRP-Bio program at MIT, working in the Vos Lab Seychelle Vos biology.mit.edu/bsg-msrp-bio-s…

The short talk abstract deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation meeting is coming up (Jan 9). The meeting is being held jointly with the Epigenetics in Development and Disease meeting, and it will be awesome! #KSChromatin25

Our collaborative AGO2 work with the Bartel lab is published! @AMohamed_98 and Peter Wang used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing

Start off the New Year on a high note and submit your abstract for Keystone Symposia Interplay of Chromatin Architecture and #Transcription Regulation, this March/April in Banff. Short talk abstract and scholarship deadline are only 1 week away! tinyurl.com/txn-keystone #KSChromatin25

The short talk abstract and scholarship deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation is tomorrow (23 January)! Get your abstracts in to be part of a great meeting in Banff this spring. keysym.us/KSChromatin25