Excited to share our recent paper detailing the development of the affinity-directed phosphatase (#AdPhosphatase) system for targeted protein #dephosphorylation 🎯 . cell.com/cell-chemical-… . Gopal Sapkota Sapkota Lab Sapkota Lab UoD Life Sciences

Introducing HiBiT-SpyTag - A Minimal Tag for Covalent Protein Capture and Degrader Development. Developed at the CPD with Breanna Zerfas Lyn Jones and the team! A thread 1/N pubs.acs.org/doi/10.1021/ac…

After a rich first day of scientific discussions, we take a stroll around Wetzlar, learning more about Goethe and the history of the town. Ivan Đikić

@SFB1177 focusing on selective #autophagy in health and disease was supported today for the next 4 years by DFG public | @[email protected] SFB network is evaluated as: “#Leuchtturm of autophagy research in Germany at the highest international level”☺️👍 Goethe-Universität IBC2 HMWK Hessen @

Christmas times at IBC2: enjoying #mitochondria cookies & listening to Jens Brüning from CECAD Cologne in a perspective lecture on how neuronal circuits regulate liver #autophagy & how the smell of food can change mitochondrial morphology. It‘s all about anticipation 🎄😋

Check out our game, DEGRADATOR! 🎮 Designed to popularize and educate on the ubiquitin-proteasome system and PROTACs. Perfect for kids 12+ but not only 😉 Dive into 10 fun levels to explore protein degradation. Available on Google Play and degradator-game.com 🚀

That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.

Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN: Cell Reports Physical Science cell.com/cell-reports-p…

Together with labs of Brian Liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. biorxiv.org/content/10.110…

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…

Research network #UbiQancer "Functionalising #Ubiquitin system against #cancer" is now supported by DFG public | @[email protected]. 🫶 Congrats to all members of TRR387 specially to Florian Bassermann TU München . 4 years of science and fun together 😀🙌🥰 More info on: linkedin.com/feed/update/ur…

Our #Cluster4Future has been positively evaluated by the jury & will be funded by @BMBF_Bund for a further 3 years! A fantastic, essential, endorsement of the cluster’s projects - breaking the mold for advancing proximity-inducing drugs in Germany! #Innovation #TPD #TechTransfer

#Degradation resistant #tumors - grant funded by German-Israeli foundation for teams from Goethe-Universität, Helmholtz Munich | @HelmholtzMunich & Technion Israel. We rented a cottage in the beautiful Swiss Alps for our retreat. Discussing science, walks, peaceful nights with stars, fondue and fun... 😊

It is finally out! My first Science Magazine paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Đikić for all the support and trust ! 🫶. Science science.org/doi/10.1126/sc…

The 2024 #Proxidrugs annual retreat was once again a great chance to meet our colleagues from the consortium. A big shout out to our team members who represented us on stage Anne-Claire Jacomin Giulio Giuliani Henry Bailey Mohit Varun Shah #Cluster4Future PROXIDRUGS IBC2