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New #preprint alert from our lab! We investigated how cellular context influences TF-driven epigenetic rewiring during neuronal differentiation. Check it out here: biorxiv.org/content/10.110…

Excited to share our latest preprint, as part of ENCODE4, on a consensus variant-to-function (cV2F) score for functionally prioritizing variants for complex disease - led by Tabassum Fabiha and co-mentored with Alkes Price. biorxiv.org/content/10.110…

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, Nature Communications, 4DNucleome, The 3D Genome, Human Genome Org, Network Science Society, @Emblebi, @MoGen_Grads

It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…

Sunshine and rainbows for the little dude #happyharryhippo

The Teves lab totally glammed it up at the department holiday party!

In this episode, I interviewed Dr. Sheila Teves (Sheila Teves @sheilateves.bsky.social) and Dr. Lawrence David with a fellow graduate student at Duke, Enya (Enya Dewars 🇵🇭🇯🇲)! Words cannot explain how fun it was chatting with other Filipino scientists 😊🇵🇭 #representationmatters

So proud of Thomas Nguyen and co-authors on the publication of this manuscript. Now out in Genetics! See full paper here! academic.oup.com/genetics/advan… Thank you to the editors of Genetics for effiecient handling, and to the peer reviewers for excellent feedback

In #GENETICS, Thomas Nguyen, Sheila Teves @sheilateves.bsky.social et al. study the regulation of Pol III transcription during different stages of heat shock stress in mouse stem cells, showing that the dynamic regulation & recovery of Pol III may be exclusive to the heat shock: buff.ly/JQLc7w1

So excited to see this work out in Nucleic Acids Res academic.oup.com/nar/article/53… Congratulations to Hazel Cui on outstanding work! Keep an eye out for part 2 of this project 😎

Vancouver showing pride

Flung some discs, shared some laughs, and capped it off with good food. Summer vibes from the Teves lab!