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The ACORN study of cefepime vs pip-tazo serves as a great lesson in how to do randomized trials in hospitalized patients. Now that we have this model, let's do more of this, please! Here's why it's so important: blogs.jwatch.org/hiv-id-observa…

For the first time, scientists have deliberately infected people with Zika virus to learn whether the strategy could help to test vaccines in the future. I wrote about the results - presented today at the ASTMH meeting - for nature #TropMed23 nature.com/articles/d4158…

Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach | Nature Immunology nature.com/articles/s4159…

In this perspective piece in ⁦PLOS Biology⁩, ⁦we discuss the importance of integrating T cell immunity as a measure of vaccine efficacy, when developing future vaccines for pandemic preparedness. ⁦Eng Eong Ooi⁩ journals.plos.org/plosbiology/ar…

New comment: Achieving zero deaths from dengue virus under evolving population immunity thelancet.com/journals/lanin…

We are hiring!!! Interested in exploring the role of T cells in the control of viral infections and cancer? Join our team Duke-NUS Medical School in Singapore 🇸🇬! Apply here: 👉Postdoc: careers.nus.edu.sg/DukeNUS/job/DU… 👉Research Assistant (Local / PR only): careers.nus.edu.sg/DukeNUS/job/DU…

Despite herculean efforts in vector control, dengue cases continue to surge. Vaccination would boost population immunity…unfortunately we still await licensing of Qdenga in Singapore (although already approved by EMA and several neighbouring countries). straitstimes.com/singapore/over…

Low-dose dengue virus 3 human challenge model: a phase 1 open-label study | Nature Microbiology nature.com/articles/s4156…

IN FOCUS: Is Southeast Asia losing the battle against dengue? With global warming, the no. of dengue infections are expected to ⬆️. Multiple strategies implemented in concert will be needed to address this increasing trend. channelnewsasia.com/asia/dengue-fe…

2024 is the worst year for dengue cases on record, with over 10 million cases already reported globally. Our latest Editorial highlights the need for a multipronged and multidisciplinary approach to halt the spread of dengue virus: hubs.li/Q02HNd1z0

Dengue virus infection among renal transplant recipients in Singapore: a 15-yr single centre retrospective review journals.lww.com/smj/fulltext/2…

OUT NOW – Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans By Shirin Kalimuddin, Eng Eong Ooi & colleagues Shirin Kalimuddin Eng Eong Ooi nature.com/articles/s4156…

The communications pause for federal health agencies meant that the CDC couldn't publish MMWR last week -- first time in the publication's 60+ year history this has happened. Not happy☹️-- MMWR is a vital communication tool about infectious threats. blogs.jwatch.org/hiv-id-observa…

Scientists have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 H5N1. Learn more in Science Immunology: scim.ag/4gA2lvT

If someone thinks the measles outbreak and childhood death in Texas are "not unusual" or that these things "happen all the time", they are deeply misinformed. Don't be fooled. blogs.jwatch.org/hiv-id-observa…

Practice-changing SNAP RCT results presented at #ESCMIDGlobal this weekend. Proud that Singapore has been part of this global platform trial for Staph aureus bacteremia, with 3 sites including SGH Singapore General Hospital (SGH), TTSH & NUH.

Registration for the SgSI’s 15th Annual Symposium 2025 is now open! 📅 29–30 May 2025 📍 LKCMed Auditorium @ NTU Novena, SG Explore the latest in: 🔹 Innate Immunity 🔹 Infectious Disease & more! 🌟 Top local & international speakers 🔗 Register now: forms.gle/AcrxFTKVG3YEbS…

Why do some people not get sick even when exposed to a virus? 🤒 Prof Peter Openshaw explains how 'human challenge models' let us observe infection before symptoms start—a real-time map of the immune response in action. Read more in EMJ Reviews 👇 emjreviews.com/microbiology-i…