Beautiful piece of work addressing two fundamental chemical problems: 1. Fast lateral diffusion of membrane probes. 2. Poor brightness of ON/OFF switchable fluorescent dyes. #SMLM #superresolution #cyanine

Things are getting interesting with the #cyanine photolysis! Jeff Chan shows an incredible application of the previously undesirable cyanine photo-instability – Nanogel-based payload delivery! #chemtwitter #drugdelivery #photochemistry

Super-elegant total-synthesis of Aurachin D analogs targeting cytochrome bd oxidase in #MTB. Pleased to see this in print. Incredible work Aggie Lawer!! ACS Med Chem Lett #Tuberculosis Total Synthesis

Dual reactivity disulfide bridging enables bi-modal protein conjugation. This "stable-labile" re-bridging strategy enables native chemical ligation. #ADC #disulfidelabeling #bioconjugation DOI doi.org/10.1039/D2SC04…

Priceless opportunity!! Chemjobber #AcademicTwitter #NIH

This is fantastic!! Fox Lab at UD

Don’t play by the rules!! #DiversityandInclusion in #Science

Cleavable linkers are key in the design of antibody-drug conjugates. Wagner/Chaubet group - BFC & co-workers - present a family of acid-cleavable cyclic acetals, which are stable in plasma and readily cleaved in lysosomes, with demonstrated efficacy in mice. go.acs.org/2y0

Last month we introduced fluorous soluble SWIR dyes, this month we are very excited to finally share water soluble SWIR dyes! chemrxiv.org/engage/chemrxi….

One of our most read articles this month is One-Step Conversion of NHS Esters to Reagents for Site-Directed #Labeling of IgG #Antibodies by Gothelf and coworkers iNANO - Interdisciplinary Nanoscience Center go.acs.org/2LV

Go Jess!!

ENCTACS enable localized formation of degraders resulting in precision TACs! science.org/doi/10.1126/sc…

An Account on our efforts in fluorescent probes for plasma & organelle membranes is out in Acc Chem Res ACS Publications. Big thanks to colleagues of my team & collaborators for years of fruitful work! - CNRS Alsace European Research Council (ERC) ANR - Agence nationale de la recherche pubs.acs.org/doi/10.1021/ac…

Why does Trodelvy’s carbonate linker work so well? Is the rate of free-payload delivery at target site is crucial? Can the deconjugated antibody help better #ADC penetration? Excellent work on the holistic approach in #ADC development by Thurber et al. doi.org/10.1158/1535-7…

Thrilled: Jan's thioredoxin anticancer prodrugs hit ACS Central Science! 5 years, 10 duocarmycins, 177 cell lines, & in vivo. We add cyclic RSSR'/RSeSR' motifs to the toolchest of bioreductive prodrugs (quinones, nitroaryls, N-oxides). pubs.acs.org/doi/10.1021/ac… ChemBioEurope BogerLab

Check out this amazing new work from my colleague Euna Yoo on using natural products as inspiration for covalent ligand discovery in J. Am. Chem. Soc.! pubs.acs.org/doi/full/10.10…

Excellent example of informing covalent latent ligand discovery from natural product chemistry.

Matthew Bogyo, @__mguerra__ & co-workers introduce probes and a camera system that enable real-time ratiometric imaging of solid tumors in an intraoperative setting to overcome limitations of previous one dye systems. NEW #ASAP. Read it here: go.acs.org/5a5

Very proud that our review on systematic analysis of brightness of fluorescent nanomaterials is out in Chem Soc Rev! Congrats and thanks to co-authors! CNRS 🌍 - European Research Council (ERC) Open access link: pubs.rsc.org/en/content/art…

He 5X'ed AstraZeneca's productivity from pre-clinical to phase III completion and transformed the company's R&D strategy, culture and approach to innovation. I spent hours researching Mene Pangalos. 10 key principles from his leadership playbook: