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Check out our new preprint in collaboration with the Sigel Lab and find out more about Theta Ribozymes: Thousands of novel HDV-like, self-cleaving ribozymes that are often found next to viral tRNAs. biorxiv.org/content/10.110… #tRNA #biochemistry #ribozymes #bioinformatics

Last friday the Sigel group traveled to Bern. Why? To learn about RNA research in Switzerland at the Swiss RNA Workshop. Besim Fazliji, a Ph.D. candidate in our group, gave a talk about " Dissecting the exon binding mechanism in group II intron splicing" - and it was great!

We congratulate Federico Held for completing his master thesis with us. Federico introduced a heteroatom into RNA and used this to look at the BCL-2 RNA G-quadruplex. Thanks for the great time Fede!

Did you know that gut bacteriophages can switch between distinct genetic codes? We may have discovered key players in this code transition, theta ribozymes. Summary below, read the full story here: nature.com/articles/s4146… 🧵1/6

The Sigel group is starting into summer with two new members: We welcome Benjamin and Matteo for their Master projects! Benjamin is doing a specialized Master in our NMR subgroup while Matteo is doing smFRET studies. We wish few failed experiments and lots of fun in the lab!

The chemistry booth at Science and Nature Festival powered by the Sigel lab - come join us at Campus Irchel today!

After 9 months it is time to say goodbye to our Japanese exchange student Minako - thank you for all the work you put in your NMR studies and, of course, the delicious cake!

We are delighted to announce the Inorganic Chemistry Frontiers Outstanding Paper Awards 2014–2023！ Please join us in congratulating our winners, we hope you enjoy reading their outstanding articles as much as we did. rsc.org/journals-books…

Do you want to assign solution structures of G-quadruplexes using NMR? Maybe this new approach we just published works for you. Congrats to Zhenghui and Carla for this amazing work! doi.org/10.1039/D5SC01…

Congratulations to Matteo Lisibach for winning the Semesterpreis of the University of Zurich for his outstanding master thesis entitled "Toward multiple coordinates: Resolving the intrinsic heterogeneity of a group II intron folding and splicing process". Very well done Matteo!