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(1/3) We are excited to share our new paper now out in PNASNews. pnas.org/doi/10.1073/pn… #circadian #adipogenesis #obesity

We're proud to announce our latest preprint, "High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells", out now on biorxiv biorxiv.org/content/10.110…! [1/7]

Have you ever wondered how to confine bi-stable chromatin states effectively? Then please check out the new preprint from Jan Fabio Nickels and kim sneppen biorxiv.org/content/10.110…

And we're now online at Cell Systems! Check out the updated paper for some new analyses and overview figures that emphasize the impact of understanding transcriptional regulation by viral proteins. sciencedirect.com/science/articl…

Our latest paper is out today (with A. Xiyal Mukund Josh Tycko and many other talented trainees): High-throughput functional characterization of combinations of transcriptional activators and repressors, at Cell Systems cell.com/cell-systems/f…

New preprint! We studied how single-cell 3D chromatin structure changes under targeted epigenetic perturbations using multiplexed DNA FISH and synthetic biology tools, and found an intriguing relationship between chromatin compaction and epigenetic memory. biorxiv.org/content/10.110…

We’re excited to announce our new preprint, ‘The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation,’ expertly led by graduate student Joydeb Sinha! (1/9) biorxiv.org/content/10.110…

It's a double feature on epigenetic memory today! Check another amazing new preprint on single-cell chromatin compaction and memory establishment from wizard postdoc Taihei Fujimori!

🚨 New paper alert 🚨 I am so happy to share the first paper of my postdoc in Mizuno Lab . Here we hope to summarize the cellular landscape of neurons thru the lens of #cryoET. Hope you enjoy. authors.elsevier.com/c/1ivnv3PA3sYq…

We are hiring a lab manager/research assistant! More details and how to apply here: bintulab.com/2024/06/01/hir…

Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint Bintu Lab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)

Got out of the nucleus! Tested ~30,000 tiles from human RNA-binding proteins, found lots of domains that downregulate RNA&built an inducible synthetic RNA-binding protein for keeping target RNA at constant intermediate levels: biorxiv.org/content/10.110… So many follow-up projects!

Delighted to see our work tiny.cc/icuazz from the Canzio lab UC San Francisco on how #cohesin-mediated enhancer-promoter interactions shape stochastic #Protocadherin choice profiles out Science Magazine. #epigenetics #chromatin #DNAmethylation #LoopExtrusion #CTCF #3Dgenome. (1/8)

I’m amped to share our new work to decrypt transcriptional repressors, now on bioRxiv: biorxiv.org/content/10.110… We paired deep mutational scans with machine learning to predict and even tune repressor activity. (1/8)

Our new paper on epigenome editing is out! We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability nature.com/articles/s4158…