
Sirimuvva Tadepalli
@siritadepalli
@LSRFdtn fellow tumor immunology, dendritic cell biology @Idoyaga_Lab @StanfordMed
Previously, bio-nano interactions, biomaterials SoftNanomaterials Lab @WUSTL
ID: 1637976026696540161
21-03-2023 00:34:59
23 Tweet
74 Followers
104 Following


Focal RT trigger rapid recruitment and activation of monocytes promoting anti-tumor immunity⦠while not-so-focal RT affecting healthy tissue hamper this effect. Really cool study in ā¦Science Immunology⩠𤩠science.org/doi/10.1126/scā¦



Our work on perforin-2, a pore-forming protein expressed by #DendriticCells to deliver antigens into the cytosol during #CrossPresentation is now out in Science Magazine science.org/doi/10.1126/scā¦ā¦ Huge amount of work from Pablo, in collaboration with Marco Laub & Patrycja Krawczyk


Read this week's Cancer Discovery #ResearchWatch: Conformal Radiotherapy Efficacy Depends on Monocyte IFN-I Signaling, summarizing the work of Sirimuvva Tadepalli, Derek Clements, Idoyaga Lab et al. bit.ly/44i51IC Stanford Medicine






Our latest paper on transitional dendritic cells (tDCs), led by Fernando Sulczewski RaĆŗl Maqueda @marce_immune, is now online Nature Immunology. We are very excited to share our findings related to the origin and function of this enigmatic DC population! š§µš nature.com/articles/s4159ā¦

Congrats to Elana Ben-Akiva Johan Karlsson & team on #immunoengineered #nanoparticles for targeting dendritic cells for next generation #mRNA #cancer #vaccines! hopkinsmedicine.org/news/newsroom/⦠pnas.org/cgi/doi/10.107⦠Hopkins Med News Johns Hopkins BME The Johns Hopkins Institute for NanoBioTechnology NIBIB

We are excited that our latest study on cDC1-mediated coordination of anti-cancer responses by tumor-infiltrating TCF1+stem-like CD8+ T cells, led by PhilippaMeiser is now published OPEN ACCESS in Cancer Cell! cell.com/cancer-cell/fuā¦ š§µš1/n


#Radiotherapy not only kills tumors but also shapes #immunity. Idoyaga Lab reveal that in radioresistant tumors, clinically relevant radiotherapy induces GM-CSF secretion, driving immunosuppressive monocyte-derived dendritic cells and regulatory T cells. hubs.la/Q03dGdSX0


Our latest Journal of Experimental Medicine paper is out! Radiotherapy induces GM-CSF in melanoma, driving monocytes to become regulatory monocyte-derived dendritic cells (moDCs) - traced with Ms4a3-TdTomato mice! Huge shoutout to Sirimuvva Tadepalli + Derek Clements for leading this!