🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

I am so excited to share our review on microglial heterogeneity Nature Neuroscience! It was a fantastic effort by the lab, led by Laura Fumagalli and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. nature.com/articles/s4159…

Wonderful evening with Shane Liddelow following his visit to Imperial Department of Brain Sciences UK Dementia Research Institute 🧠

Really nice work from the Alexi Nott 🏳️‍🌈 lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, Reuben and Alexi 👏🏻✨

Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type deconvolution in brain studies of histone acetylation. Reanalysis of bulk data from >300 samples revealed novel cell type specific epigenetic associations👇🏻

Dr Sarah Marzi gave an exciting presentation at #BioKorea2025, "Using epigenetics to understand how different brain cells malfunction in Importance of Epigenetics #AlzheimersDisease. Institute of Psychiatry, Psychology & Neuroscience UK Dementia Research Institute King's College London AD/PD - Advances in Science & Therapy

How do proteins involved in the metabolism of fats in the body change your risk of developing #Alzheimer's disease? A new study from Sarah Marzi and UK Dementia Research Institute in Nature Communications looks at differing versions of the APOE gene and the effects on the brain. kcl.ac.uk/news/different…

STUDY by Sarah Marzi, Kitty Murphy, et al. offers clues into how APOE isoforms differentially affect human #Microglia function in #Alzheimers, suggests how APOE2 is protective while APOE4 increases disease risk by regulating brain's immune cells Nature Communications nature.com/articles/s4146…

The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's, but different versions of the protein confer strikingly different risk profiles. New research led by Sarah Marzi offers insight into how the different versions of APOE affect

What is epigenetics, and could it be important in the development of motor neuron disease / ALS? 🤔 At the UK DRI at King's, Group Leader Dr Sarah Marzi lab is using cutting-edge genomic techniques to study how environmental factors over our lifetime can alter gene regulation in

🎙️ New podcast: Between the signals - What is motor neuron disease?🎙️ Ahead of #GlobalMNDAwarenessDay, UK DRI at King's have launched a new public podcast aimed at increasing understanding about neurodegenerative conditions Listen or watch episode 1 👉 ukdri.ac.uk/news-and-event…

Really excited to speak at the Canadian Conference on Epigenetics. Join us in beautiful Banff in November 👇🏻

Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: Jonas Neher, Susanne Kooistra, MINDlab. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.