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Congrats Prashant Bhat Mitch Guttman ! Happy to have contributed to this project showing how genome organization around nuclear speckles impacts RNA splicing efficiency!

How do you turn a condensate inside-out? Congrats to Sofi Quinodoz & Lifei jiang & co-authors on amazing study from our lab & Denis LJ Lafontaine + Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) biorxiv.org/content/10.110…

Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating the lifecycle of RNA, the regulatory roles of RNA, the importance of RNA in disease, and the technologies used to study RNA. cell.com/molecular-cell…

It has been a wonderful journey uncovering the mysteries of the multiphase nucleolus🤯🤩! So lucky to drive this project together with amazing postdoc Sofi Quinodoz brangwynnelab, and awesome collaborators, utilizing genomics, imaging, engineered rDNA🧬, and modeling approaches.

Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.

Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of Sofi Quinodoz & Lifei jiang w/ Denis LJ Lafontaine & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…

Combining sequencing and imaging, Sofi Quinodoz maps the spatiotemporal dynamics of rRNA processing, demonstrating how rRNA serves as both a scaffold and a substrate for the nucleolus—a multiphase, liquid-like structure. nature.com/articles/s4158… brangwynnelab Omenn-Darling Bioengineering Institute