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The devil is in the details: a synonymous SNP in ompk36 induces an inhibitory 2ndary mRNA structure & increases Klebsiella #AMR. Great collaboration linking genomics Sophia David, structural biology Research Complex at Harwell & @RouskinLab & public health Azienda Ospedaliero-Universitaria Careggi pnas.org/doi/10.1073/pn…

Our latest paper on #Legionella revealing disease-casing clones endemic to Scotland. Well done Jamie Gorzynski Bryan Wee and others The Roslin Institute Edinburgh Infectious Diseases Public Health Scotland NHS Greater Glasgow and Clyde

Phew! - We finally got this out, and whilst twitter is still a thing. Thanks to all co-authors. lifesciencebath nature.com/articles/s4156…

Happy to share the work ‘Global scenario of the RmtE pan-aminoglycoside-resistance mechanism: emergence of the rmtE4 gene in South America associated with a hospital-related IncL plasmid’ doi.org/10.1099/mgen.0… Thanks to ARU Antimicrobial Resistance Unit, Centre for Genomic Pathogen Surveillance and IIBCAUDO for making it possible!

Do you want to know more about the secrets of bacterial conjugation efficiency & specificity? Are you familiar with Wen Wen 's previous work & cant wait to check out her latest? Have a look at our new publication on TraN-OMP pairs in conjugation! 🦠➡️🦠 pubmed.ncbi.nlm.nih.gov/36988519/

This first dive into Klebsiella genomic surveillance in Wales now out in #MGen Microbiology Society microbiologyresearch.org/content/journa… thank you to all co-authors.

Our editorial on navigating the AI frontier in microbial genomics research is out today in Microbial Genomics doi.org/10.1099/mgen.0… co-authored by Niamh Page and Sheppard Lab

Now why do you think MBL-producing #CPE would have a higher attributable mortality than non-MBL-producing CPE (in this large Italian cohort study)? reflectionsipc.com/2023/06/30/cpe…

I put together a somewhat extensive course for intro to pathogen genomics analysis, which I trialed here in Kigali these past 2 weeks. Please share with anyone you think may benefit from it. conmeehan.github.io/PathogenDataCo… A mini-🧵overview of its content:

Very happy to share our review and view on bacterial conjugation Plasmids pick a bacterial partner before committing to conjugation academic.oup.com/nar/article/do…

Excited to see our bacterial mutational spectra paper out We show that mutational spectra can be associated with bacterial niche and transmission routes nature.com/articles/s4146… Thread below 🧵 1/12

Thrilled to share that our latest study has been published today! We take a look at how the capsule serotypes of Klebsiella pneumoniae influences phage adsorption and infection, and plasmid conjugation efficiency. Thread👇 #Capsule #Klebsiella #Phage #Plasmid #Conjugation

I'm recruiting for a new post-doc role based in Melbourne and contributing to #klebNET-GSP activities on #klebsiella genomic surveillance. Sylvain Brisse @DrKatHolt Centre for Genomic Pathogen Surveillance @chcrestani Tom Stanton Sophia David Theycallmemaggie Check out the details ⬇️

Is it worth sequencing large species collections? I think we can still learn new things about seemingly well-characterized bacteria such as Klebsiella pneumoniae #klebclub. Happy to share insights from COMBACTE CARE EURECA which we compared with the EuSCAPE dataset 🧵1/7

📢 New preprint!! Combining transcriptomics, genetic engineering and CRISPRi silencing, we unveiled a plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria - 1/10 🧵👇 biorxiv.org/content/10.110…

We are happy to share our recent results on conjugation surface exclusion with a chromosomal twist. Must mention Chloe’s and Sophia’s incredible contributions. Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT biorxiv.org/content/10.110…

So exciting to see our (Liam Shaw, @Sheppard_Lab, Ed Feil) piece on the current state of plasmid epidemiology is now out: microbiologyresearch.org/content/journa… Nuffield Department of Medicine Oxford Biology Ineos Oxford Institute for Antimicrobial Research Milner Centre for Evolution

Our latest preprint is out describing amr.watch – a platform for monitoring AMR trends from global genomics data. Supporting all WHO priority pathogens (2017), amr.watch summarises the geographic and temporal distribution of genotypic variants (e.g.

Our preprint on using genomics to explore vaccine target diversity⬇️ A real pleasure working on this with Khalil Abudahab and the team. We're keen to gather feedback, feel free to get in touch (although I will be a little quiet for a while due to another project arriving soon!👶)