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So excited to share our #RheumatoidArthritis tissue chromatin atlas of 87K cells from 30 individuals! With, Soumya Raychaudhuri সৌম্য রায়চৌধুরী, Saori Sakaue, Aparna Nathan, Laura Donlin, Kevin Wei and #AMP-RA! NIAMS. biorxiv.org/content/10.110… (Tweeting on behalf of the talented Kathryn Weinand)

SCENT defines non-coding disease mechanisms using single-cell multi-omics go.nature.com/3R8yu3X #ToolsoftheTrade by Saori Sakaue Harvard Medical School Broad Institute #NRGToT

Our AMPRA study defining the key chromatin classes in inflammatory tissue from #RheumatoidArthritis is out. We argue: single cell chromatin class profiles encompass multiple single cell transcriptional states. NIAMS Broad Institute Brigham and Women’s Research link.springer.com/article/10.103…

AMP-RA study defining chromatin states in inflammatory #RheumatoidArthritis tissue is out! We argue: single cells can be grouped into chromatin classes, encompassing multiple transcriptional cells states. NIAMS Broad Institute Brigham and Women’s Research link.springer.com/article/10.103…

The Leena Peltonen Prize of 2024 goes to Sasha Gusev 🎉! I was honored to announce this and introduce Sasha just minutes ago at #ESHG24. Huge congrats!

Lappalainen Lab Sasha Gusev Congratulations Sasha Gusev🎉!

Congratulations Sasha Gusev ! So well deserved!

Thrilled to announce that I got promoted to professor at Keio University School of Medicine (Department of Microbiology and Immunology) Keio University. I will manage two labs at Keio (faculty.med.keio.ac.jp/en/research/fa…) and Riken (riken.jp/en/research/la…).

Amazing Kaz - congratulations!

Congratulations to Saori Sakaue and UW Genome Sciences for the launch of what I am sure will be an amazing research group! So excited!

Million Veterans Project is out! Congrats Kat Liao and team! science.org/doi/10.1126/sc…

Excited to share our HLA-pQTL study revealing widespread HLA trans effects on protein expression in UK Biobank- now out at Nature Communications with Xinli Hu, Josh Chiou, Soumya Raychaudhuri সৌম্য রায়চৌধুরী, Saori Sakaue, Joyce Kang, PhD, and many more Pfizer Inc.! nature.com/articles/s4146…

Big thanks to CZI Science for the opportunity to keep working on Harmony with Martin Hemberg and Soumya Raychaudhuri সৌম্য রায়চৌধুরী! If you haven’t already, check out the much more scalable Harmony v1 on CRAN and GitHub/immunogenomics

Hi friends! Genotype-Neighborhood Associations (GeNA) by Laurie Rumker et al is now published! Broad Institute Brigham and Women’s Research nature.com/articles/s4158…

I’m so excited to share the first pre-print from my lab at UCSD and the work of two excellent undergraduate researchers. We designed a new method to enhance eQTL mapping in small cohorts and thus improve disease-gene inference in non-EUR populations. medrxiv.org/content/10.110…

It was a great visit to Princeton University. Thanks so much for hosting me Yuri Pritykin!

Check out our latest #DeepLearning method to analyze spatial molecular data from Yakir Reshef!

Problem: eQTL reveals disease alleles' function on gene expression, while it's been so puzzling🧐 that most #GWAS alleles do not colocalize with #eQTL. The traditional wisdom in the field is that eQTL regulate DNA transcription in the nucleus by altering regulatory sequences (2/n