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🧵/RCTs are the gold standard in⬇️ biases in📝. But often times, obtaining funding & enrolling based on honest power calculations is impossible, esp in Surgery. That means most📝are cohort studies, & I thought it’d be worth reviewing what one can do to best adjust for biases.

Congratulations to Dr. Monica Bertagnolli on her confirmation today by the U.S. Senate to serve as director of the NIH. The AACR looks forward to working with Dr. Bertagnolli to advance biomedical research and the health of all Americans. Dr. Kimryn Rathmell

👇🏽 First CRISPR-based medicine approved Amazing new option for patients with sickle-cell disease & b-thal MHRA authorises world-first gene therapy that aims to cure sickle-cell disease and transfusion-dependent β-thalassemia - GOV.UK gov.uk/government/new…

10/In this opinion piece for STAT, leading pediatric surgeons Francois Luks, Tippi MacKenzie, and @TomTracyMDMBA call out the serious threat abortion restrictions pose on fetal surgery. Again, abortion rights are synonymous with reproductive rights. statnews.com/2023/12/05/fet…

Truly the end of an era. A legendary surgeon, teacher, & mentor whose passion for vascular surgery inspired me & so many others. Wishing the best for your more than well deserved time with family, friends, & 🏌🏼. I'm honored to be #BelkinTrained BWH Vascular Surgery Brigham and Women’s Department of Surgery

Remember how I said the next gen is just 🔥? Serena Dasani is former chief res Brigham and Women’s Anesthesiology and was a #Fulbright scholar in Indonesia. She's also a proud mama to identical twin girls with a passion for empowering women 🫶🙌and improving healthcare management! #WIAWednesday

Why does Moderna not become THE gene editing company? endpts.com/jpm24-moderna-… This serious question has a serious, substantive answer. Moderna has the delivery technology - LNPs it can make at global scale! - the ability to make the mRNA CRISPR payload - also at global scale! -

A fascinating hypothesis and slick execution of an experiment with wide reaching consequence. Stabilizing mRNA for vax and tx might alter the desired protein. But also here’s a mitigation measure.

#CRISPR is a platform for cures. Intellia Therapeutics describes a second "nothing but net" clinical dataset on liver editing that, technologically, is a copy-paste of an earlier such effort (34215024) in a different disease. Only the guide RNA is different. nejm.org/doi/10.1056/NE… We

This is the scariest thing I’ve read in, maybe ever Incredible work in NEJM nejm.org/doi/full/10.10…

Congrats to our incoming categorical general surgery residents Brigham and Women’s Department of Surgery. Looking forward to working with all of you!

So proud of Serena Dasani recognized at Society of Cardiac Anesthesia as outstanding fellow this year. Brigham and Women’s Anesthesiology #bestinshow

More WICTA #SCA2024 award winners! Dr. Agniezska Trzcinka, Dr. Sujana Bhandary, and Dr.Jessica Zvara won Karen Souter coaching scholarships. In the outstanding fellow category, the awards went to Drs. Serena Dasani and Ariana Cook. Congrats to all the winners! Society of Cardiovascular Anesthesiologists | SCA Thoracic Anesthesia Symposium | SCA

🎉 Huge congratulations to Serena Dasani for receiving both the WICTA Fellow of the Year Award and the SCA In-Training Grant! 🏆 Keep up the great work! WomenInCTAnes Brigham and Women’s Anesthesiology Society of Cardiovascular Anesthesiologists | SCA Mass General Brigham #BWHCardiacAnesthesia #SCA2024

An incredible privilege in the penultimate week of chief residency to hear from Brigham and Women’s Department of Surgery legend and NIH Director Dr Bertagnolli commemorating Dr Nina S Braunwald, introduced by the also legendary Zara Cooper. “It’s great to be Brigham trained.”

A bit of poorly written surgical fun. Composed on the Brigham and Women’s Department of Surgery Cushing trauma service.

Our latest collaboration and another labor of love from William Peranteau and Mike Mitchell. Targeting hematopoietic stem cells for gene editing in the fetus employing targeted ionizable lipid nanoparticles. roro CHOP Fetal Center | PNAS pnas.org/doi/10.1073/pn…

Fellows who happy hour together operate better together. Study forthcoming. A rare sighting of the majority of 2024 Texas Children's ENT, GYN, Urology, and TCH Pediatric Surgery fellows. BCM_Surgery

Check out our bioRxiv describing our efforts to treat a severe vascular disease 🫀: 1️⃣ Optimization of a target-specific base editor🧬 2⃣ A *must avoid* bystander edit prevalent with WT SpCas9 BEs! 🙅‍♂️😱 3⃣ Substantial extension of lifespan following in vivo base

Stepping stones but this one is a big one. nejm.org/doi/full/10.10…