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After a long day yesterday (baby appointment-experiments-back home🧑‍🍼&👶💤) & regaining some energy, I’m excited to share our work published in Nature Cell Biology rdcu.be/dNyYD. Huge thanks to Spencer Freeman Amra Sarić stefan uderhardt 🔬🧫💉📷, Sergio and all coauthors for making this happen!

Our work on ERM proteins in macrophage migration and cortex mechanics is out in the EMBO Journal 🎉 embopress.org/doi/full/10.10… Great review process by Review Commons 🙏 And here is a thread on this story: x.com/RenaudPoinclou…

💫Spencer Freeman, Ruiqi Cai & co show that, in macrophage lysosomes under hydrostatic pressure, mechanosensitive channels cause a cation leak, mTORC1 inhibition, TFEB/TFE3 activation and release of monocyte chemoattractant proteins. 👉🏻rdcu.be/dQQyn nature.com/articles/s4155…

Excited to share our paper just out in Nature today! Proud of my amazing Postdoc Dr. Akriti Prashar for this outstanding work! Self-repairing mitochondria use novel recycling system, study finds sickkids.ca/en/news/archiv…

"News and views" from nature describing our groundbreaking study out today in Nature 🎉 So proud of Dr. Akriti Prashar and the Jones lab team and our collaborators! The Hospital for Sick Children (SickKids) Inner membrane turns inside out to exit mitochondrial organelles nature.com/articles/d4158…

Interested in podosomes? This #JI_TopRead identifies regulators of podosome formation. Discover the key signaling events by reading this study by S Ghasempour, Aleixo Muise, & Spencer Freeman: ow.ly/JAIV50TFWFk. #ReadTheJI #immunology

You don't want to miss this amazing event celebrating 40 years of the TCR. Be there Thursday October 31st, 2024, 8:30 – 5:45pm, Macleod Auditorium, St. George Campus. Please RT! Temerty Medicine , University Health Network , University of Toronto issuu.com/irenemng/docs/…

Sickkids team running for Crohn's and Colitis Canada. Beautiful fall day in Toronto. #toronto5k

One of the most inspiring talk #FromCelltoOrganism2024 @sbcf1 SFBD-BioDev was given by Spencer Freeman Spencer Freeman The Hospital for Sick Children (SickKids) on #lysosomes

Excited to share that our story on apolipoprotein control of cross-presentation is now published in Science Immunology and can be found here science.org/doi/10.1126/sc… Congrats first authors Gerone Gonzales , Liam Wilkinson and Song Huang, as well as Cassie Wood and xless authors too. 😊

Ghasempour et al. The Hospital for Sick Children (SickKids) use whole exome sequencing in #IBD patients to reveal variant of ITGAV that impair #integrin function, including downstream TGF-β signaling, as determined in patient cells and modeled in zebrafish. hubs.la/Q02XKzWX0 Marco Rodari @marparl1

Scaffolding of NLRP3 on osmotically swollen vesicles but not intermediate filaments promotes inflammasome assembly biorxiv.org/cgi/content/sh… #biorxiv_cellbio

"vimentin was dispensable for activation of caspase-1, IL-β cleavage & release...NLRP3 was found on osmotically swollen PI4P- LAMP1-positive compartments. These results...suggest NLRP3 may be activated by...high membrane tension on vesicular compartments" biorxiv.org/content/10.110…

How it may be possible to maintain integrity of the blood brain barrier that is dysregulated during aging nature.com/articles/s4158… nature Carolyn Bertozzi Stanford Medicine nature.com/articles/d4158…

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum; hopefully a useful concept😀. Snapshot below and Open Access here: embopress.org/doi/full/10.10…

Pemberton, Burke, Balla NICHD News et al report the generation & characterization of an engineered active fragment of PIKfyve and its use to generate extra PI(3,5)P2 in endomembrane compartments & test the function of PI(3,5)P2 #biosensors hubs.la/Q03dyfL60 #lipids

Wu et al The Hospital for Sick Children (SickKids) show that Snx10 regulates PI(3,5)P2 accumulation on #lysosomes by controlling PI(3)P delivery. Deleting Snx10 inhibits ClC-7, thereby impairing (phago)lysosome resolution. This mechanism may account for Snx10-related #osteopetrosis hubs.la/Q03dym0b0

We’ve engineered stable cell systems to induce lipid scrambling of the plasma membrane with active forms of TMEM16F. Scrambling alone causes vesiculation (🔵TMEM16F; 🟠PS/Annexin V). Let us know if you want to try the cells out. Preprint: biorxiv.org/content/10.110…