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My postdoc adventure🇬🇧concludes with a new preprint! Contrary to textbook depictions, we found that small vesicles mostly diffuse. Diffusion of INVs is even sufficient to explain their transport to the plasma membrane during exocytosis! 📜with Rhys Denver: tinyurl.com/564r3bbd

"Foldy: a web application for interactive protein structure analysis" Provides a GUI for AlphaFold, AutoDock, & others. Server: foldy.lbl.gov Preprint: biorxiv.org/content/10.110…

How organelles respond to external forces? Do organelles play any role in mechanotransduction? We tried to answer these emerging questions in a new review we wrote together with Hesso Farhan @patriziaromani doi.org/10.1016/j.tcb.…

It was indeed great fun working on this! Many thanks to Hesso Farhan for this opportunity.

Interested in the role of subcellular organelles in cellular #mechanotransduction? Then our (Hesso Farhan, Sirio Dupont, @patriziaromani) review, out now in Trends Cell Biology, might be something for you. We sum-up existing literature and list open questions doi.org/10.1016/j.tcb.…

Mechanobiology of organelles: illuminating their roles in mechanosensing and mechanotransduction dlvr.it/Spd7Kj

Our new letter on a misrepresented clinical trial has been published in Nature Cancer. In short: just because a drug inhibits a protein, you can’t necessarily conclude that that’s the drug’s MOA. Particularly when a decade of research show otherwise. nature.com/articles/s4301…

Introducing "data-to-paper": autonomous AI research! We've let it play with the large CDC Health Survey Dataset. Went to lunch. When back, it had already chosen several research topics, wrote data analysis codes, interpreted results and wrote 5 transparent, reproducible papers.

This is cool!

New mechano-regulated penotypes to explore and play with!!! 🤩 Congratulations Mooney lab Wyss Institute doi.org/10.1038/s41551…

We are offering 3 positions: 2 postdocs and 1 PhD student to work in my group or in the group of Francesco Baschieri @F_Baschierion the crosstalk of mechanobiology, cancer, and membrane biology. More information under jobrxiv.org/job/medical-un…

We are recruiting! Looking for 2 postdocs and 1 PhD student who would like to work on #cancer #mechanobiology in the middle of the Alps. More info on #jobrxiv

TFM got a new brother: CFM (Confinement Force Microscopy) allows you to confine cells, tissue and even embryos between two elastic hydrogel planes: t.ly/G0ok0. We can study key migration processes like durotaxis 👇, AND get the 3D traction forces at the same time 🤩

1/ New preprint from our lab by Zay Khan in collaboration the Jerome-Majewska and Heyd groups. We identify a novel link between splicing and ER-proteostasis #proteostasis #endoplasmic_reticulum #COPII biorxiv.org/content/10.110…

Fun collaboration with the Sadelain Lab Memorial Sloan Kettering Cancer Center, led by Michelle Saetersmoen, Ivan Kotchetkov and Lamberto Torralba-Raga. Targeting HLA-E Positive Cancers with a Novel NKG2A/C Switch Receptor Precision Immunotherapy Alliance UiO - Det medisinske fakultet Oslounivsykehus biorxiv.org/content/10.110…

1/14 I’m thrilled to share our preprint:“ForceChrono Probes for Deciphering Single-Molecule Force Dynamics in Living Cells”, a new force probe that can simultaneously measure the loading rate, duration and magnitude of receptor forces at the single molecule level.

The review we wrote together with Javier Vera Lillo and Julia von Blume @LabVonon on "Protein #Condensates in the Secretory Pathway" is already online at Biophysical Journal. Check it out if you are interested! 👉 sciencedirect.com/science/articl…

Excited to announce the first review from the lab is now available online. If you love #mitochondria take a look at our exploration of this topic in innate immunity. MRC MBU MRC MBU Postdocs Eloïse Marques 'Multifaceted mitochondria in innate immunity' nature.com/articles/s4432…

Collective cell motion has many forms, but rotation is the coolest of them all. I'm Nimesh Chahare, and in this short🧵, I'll highlight some instances of global tissue rotation like this one from BauschLab

Off to bluesky sphuyal.bsky.social