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Plants take up iron to avoid nutritional stress. Yet they should limit iron availability to pathogens, which need it for growth. @nature read how plants achieve the right balance in their roots. shorturl.at/pvCJL & shorturl.at/efiHS

Cellular organelles exchange molecular information through transient contact sites, which are sensitive to experimental analysis. Reporting @nature, scientists use advanced microscopy to map and analyse dynamic subdomains at ER-mitochondria contact sites. shorturl.at/jAX39

To restore cellular homeostasis, stress responses should be turned off at the right time and place. A paper @nature shows a ubiquitin-dependent mechanism through which unimported mitochondrial proteins silence the integrated stress response. nature.com/articles/s4158…

For targeted protein degradation, which is of therapeutic interest, either PROTACs or molecular glues are used. nature presents a third modality -- intramolecular glues that bridge protein domains within the same target to facilitate their degradation. shorturl.at/mpqt3

While Ca2+ is an essential nutrient and signalling molecule, too much of it can be toxic inhibiting plant growth. An @nature study describes two signalling pathways that converge to regulate cytosolic Ca2+ homeostasis, balancing plant growth and immunity. shorturl.at/yDP35

In plants, TIR-domain receptors mediate recognition of strain-specific pathogen effectors. A paper @nature shows that the cell-death-inducing activity of these proteins, in response to pathogens, involves their condensation by phase separation. shorturl.at/wLRT1

Targeted protein degradation/ stabilization are of therapeutic value, but only few E3 ligases and deubiquitinases have been of use for this purpose. Work ⁦⁦nature⁩ adds to this repertoire, providing a catalogue of effectors of protein stability. nature.com/articles/s4158…

Work @nature shows that the plant micronutrient zinc acts as an intracellular second messenger to mediate adaptation of the root nodule function to environmental nitrogen conditions, by controlling the activity of a transcription factor. nature.com/articles/s4158…

Glutamylation is the most common modification of tubulin, affecting microtubule function and so related cellular processes. Work @nature shows how the enzyme CC5 removes this modification, providing mechanistic insights into erasing of the tubulin code. rb.gy/m4f8dr

Using a chemical approach and extensive cryo-EM analysis, @nature researchers offer a continuum of structures for the transthiolation reactions that occur during the process of ubiquitination. nature.com/articles/s4158…

When it comes to dealing with stress, cells are resourceful. A paper @nature describes one strategy whereby, in response to oxidative stress, an autophagy-like process clears vesicles derived from the inner mitochondrial membrane. search.app/ftJtzSrYvqNTAA…

The bacterial chaperonin GroEL and cofactors mediate ATP-dependent protein folding. @nature, researchers use cryo-electron tomography to reveal the conformational and functional cycle of these protein complexes directly within cells. search.app/LmLzD5p8C48jbV…

How do paternal genes contribute to post-fertilization development? A paper @nature identifies a sperm protein, which has no apparent effect on sperm development or fertilization, yet affects transcription of a maternal gene in early plant embryogenesis. nature.com/articles/s4158…

In intracellular trafficking, the ESCRT machinery mediates membrane scission of the multivesicular bodies (MVBs). Work @nature proposes that, in plant cells, this is mediated by biomolecular condensates, and depends on the condensates' physical properties. nature.com/articles/s4158…

The bigger tomatoes come at the cost of less sweetness. Work @nature offers a solution - identifying the pathway that causes lower fruit sugar content & manipulating it to get sweeter tomatoes without affecting weight or yield. shorturl.at/6en3V & shorturl.at/bNHoR

I am very sad to hear the news of Joanne Chory passing. I met her last year at a closed meeting on the role of plant science in mitigating climate change. She was inspirational for being sharp, smart, fun and lively, despite being so unwell. shorturl.at/SZVwB

‘A place of joy’: why scientists are joining the rush to Bluesky go.nature.com/4fDjzsC