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A new PACE-based system generates protein degradation tags that interact with an otherwise-inert small molecule to trigger the rapid breakdown of a cell’s native proteins, with molecular glue systems that can become useful new research tools. broad.io/Pace-News-0314…

Jay Bradner, M.D. Eric Fischer Thanks for your comments, Jay. To answer your question: 1) dTag uses FKBP12-F36V, which is 108 amino acids (324 bp). Unfortunately this size is too large to be directly and scarlessly installed using prime editing; we tried as part of our TwinPE studies (pubmed.ncbi.nlm.nih.gov/34887556/)

Having enjoyed the paper from David R. Liu, Fischer Lab, and The Amit Choudhary Lab in Science Magazine this week, we have now posted our own, complementary, taken on a bump-and-hole approach to develop an orthogonal bumped IMiD-degron pair: biorxiv.org/content/10.110….

Reminder about the seminar tomorrow - 11AM eastern time!!

Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and Hong Yue and all co-authors on this story! 1/ nature.com/articles/s4158…

Amazing discovery on how some transcription factors self-polymerize to function. Opens the door for yet another ligandable way to target the function of these "undruggable" proteins. Congrats on making the cover Paul Park and Jiho Park!

Extremely excited about our next in-person TPD event. If you are in Boston on September 12th - sign up and join us for a half day of science and networking! Registration link: forms.gle/a8p2ALX9n2YDWt…

We are happy to share our new preprint bioRxiv "Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics" led by Kheewoong Baek and Rebecca Metivier of Fischer Lab biorxiv.org/content/10.110…

Very excited for our next seminar this Thursday: Derek Bartlett (formerly Pfizer Inc., now UNC-Chapel Hill) will share insights on PK-PD modelling for TPD and Kyle Mangano (Amgen 🧪🔬🧬) will present how VIPER-TACs co-opt viral E3s. 👉Join us at 12 PM EST/ 6 pm CET (back to original schedule)!

We are thrilled to have @georg_e_winter CeMM return to the DFCI TPD webinar this Thursday! Georg will talk about how inhibitors can supercharge endogenous degradation mechanisms. Very much looking forward! 👉Join us at 12 PM EST/ 6 pm CET (hybrid format)

Join us for the final TPD webinar of 2024 on 12/19. @FleurMFerguson & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC" Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"

For the first TPD webinar of 2025, we are thrilled to welcome Dennis X. Hu from @drughuntersite to share industry highlights in targeted protein degradation & induced proximity. 🗓️ Jan 9 | 🕛 12 PM EST Open to all, register for free at: dfci.zoom.us/webinar/regist…

Very excited for our next seminar next week! Yuh Min Chook(Yuh Min Chook) at UTSW will share an intriguing allosteric mechanism of drug-induced XPO1 degradation, mediated by the CRL5-ASB8 E3 ligase complex. Join us at 12 pm EST (Feb 20th). Preprint - biorxiv.org/content/10.110…

Very excited for our next seminar this Thursday (March 20th): Martin Schwalm (Structural Genomics Consortium (SGC), form. Knapp lab) will discuss UPS inhibitors and Dean Clift (TRIMTECH) will share insights on hijacking TRIM21! 👉Join us at 12 PM EST/ 5 pm CET (‼️US/EU daylight saving mismatch‼️)

Join us on April 17th for an exciting double seminar from the University of Dundee Centre for Targeted Protein Degradation: Charlotte Crowe on "Mechanisms of degrader-targeted protein ubiquitinability" and Alessandra Salerno 👩‍🔬 on "FerroTACs." Details: …afarbertargetedproteindegradation.org