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Pesquisadores mapeiam genes da guanitoxina, uma das mais letais neurotoxinas de água doce Resultados serão base para o desenvolvimento de novos testes de diagnóstico molecular para detecção da neurotoxina, já relatada em lagos e rios do Brasil e exterior jornal.usp.br/ciencias/pesqu…

Join us in Puerto Rico!

It has been extremely exciting work with this project and biosynthesis in plants! Amazing challenge explore these incredible organisms and looking for cool biosynthetic enzymes! Enjoying a lot 🌿🌱🧬💚

Awesome day at the Zoo and then lunch with the lab+family! 🐻‍❄️ So lucky to be part of such a great group!

Out now in Angewandte Chemie, we highlight the awesome study by the O'Connor Lab to solve a longstanding question in the plant natural product community: biosynthesis of the infamous neurotoxin strychnine. Congrats to Sanath Kandy for putting this together! onlinelibrary.wiley.com/doi/10.1002/an…

Congratulations to Keelie Butler for passing her PhD proposal defense! Keelie was the first graduate student to join the lab and it was awesome to see all of her successes!!

We have an opening for a NIH-funded postdoc in the lab! Our research focuses on the discovery and engineering of new RiPP natural product biosynthetic pathways using bioinformatic and in vitro approaches. See details below. #chempostdoc

Chekan Lab 2022 Holiday Potluck was a ton of fun! So lucky to be part of this awesome group of scientists!

A Widely Distributed #Biosynthetic Cassette Is Responsible for Diverse Plant Side Chain Cross-Linked Cyclopeptides by Stella Lima, B Ampolini, Ethan Underwood, T Graf, C Earp, I Khedi, @mikepasquale77, Jonathan Chekan Chekan Lab at Chem + Biochem UNCG in Angewandte Chemie onlinelibrary.wiley.com/doi/10.1002/an…

Out now, we use bioinformatics+metabolomics to uncover a plant biosynthetic cassette responsible for diverse cyclic peptides. We apply this to find new NPs in Coffea. Finally, we reconstitute the first enzyme activity for a split BURP peptide cyclase! onlinelibrary.wiley.com/doi/10.1002/an…

As part of the 40th anniversary of Trends in Biotechnology, we spotlight an achievement in NP production. In 2013, Paddon et al reported 25g/L fermentation of artemisinic acid coupled with synthetic steps to yield the essential antimalarial drug artemisinin. sciencedirect.com/science/articl…

We had an awesome time at #NP2023 SIMB and got to visit SIO!

Plants 🌱 are an incredible universe to explore natural products 🪴🌿 Stoked to be part of this project

Haven't seen a better representation of what a Ph.D. is/should be. #AcademicTwitter #academia #research PhD Voice - Independently Run PhD_Genie

It’s awesome to see another paper coming out from the guanitoxin biosynthesis! Huge congrats to Shaun McKinnie and Jenny Cordoza 👏🏽👏🏽👏🏽🍾🎆🎇

Check out our GntC enzymology story out today in ACS Catalysis! Happy first first to Jenny Cordoza - so beyond proud of you! And huge thanks to our amazing coauthors (P.Y.-T. Chen Stella Lima Marli Fiore Chekan Lab Bradley Moore and Linnea Blaustein)! pubs.acs.org/doi/10.1021/ac…

My first first author paper is published! Thank you to all the wonderful coauthors and I’m excited that I get to help continue the guanitoxin project!

Come join our fantastic department!

Congratulations to Draco from our lab for defending his master's thesis! He did a fantastic job and we are impressed with all he accomplished!