🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

The difference between doing a project and presenting it. An observation can lead to many avenues of explorations before focus turns to a specific discovery. Presenting it, in a talk / paper, follows inversely, with broad perspectives coming before & after the specific discovery.

Most people suck at running meetings. They run over time, the same people talk, + nothing gets decided. Here are 10 simple steps to run effective meetings:

Meta just dropped 600+ million protein structure predictions, made using a large language model. My latest for nature nature.com/articles/d4158… 1/3

Fascinating: lactate sensor shows that mitochondrial lactate pools are ~5x bigger than nucleo-cytosolic pools cell.com/cell-metabolis…; are there implications for our reliance on whole cell pyr/lac as readout of cytosolic NAD/NADH?

Need to read this one! Important issues we need to better understand - congrats to the team!

#LiveForever! Nakanishi &co show nature that senescent cells are inflammatory & present an interferon signature, but are protected from T cell killing by up regulating PDL1, thus favoring inflammaging! Anti-PD1 decreases senescent cells in aged mice! doi.org/10.1038/s41586…

During re-infection, primed CD103+ gut TRM cells turn on but don’t expand and CD103- gut TRM cells seed and renew CD103+ TRM cell populations in gut tissue, finds a new study in mice. TU München 📄: scim.ag/qE

Dysregulation of temporal metabolic adaptability is a key 🔑 feature of #immunosuppression. Drs. Huiyang Yu, Nicolas Jacquelot, and Gabrielle Belz review how #metabolism regulates lymphocytes beyond the classical T cell subsets. 📂 bit.ly/3DkXm0G

Secreted immune metabolites that mediate immune cell communication and function dlvr.it/ScJ4bd #immunology

Identification of hematopoietic stem cells residing in the meninges of adult mice at steady state cell.com/cell-reports/f…

One of the most impressive T cell papers in the past decades. A truly humbling experiment and incredibly important insights into T cell biology. Masopust Vezys Lab truly amazing. A must read for all T cell biologist (all immunologists really). #instantclassic nature.com/articles/s4158…

Discovery of bone lymphatics & their role in blood & bone regeneration Cell 👇 cell.com/cell/fulltext/… Very grateful to: fantastic - editor & reviewers, funders Medical Research Council European Research Council (ERC) & support from @MRC_HIU MRC WIMM RMS BSCB

Amazing to see our Bone Marrow Organoid paper out today in the Feb issue of Cancer Discovery Abdullah Khan Beth Psaila Even more exciting to see an amazing Spotlight article written about it! Thank you @marta_derecka and John Crispino 🤩 - I love it! tinyurl.com/39xa82uk

1/6 📢And here it is: 😍 We are excited to announce the first international workshop on “Metabolism in the single cell era”. It will be held in Bordeaux, France from the 20th to 22nd of September 2023

IL-23 signaling is required for baseline and IL-23-inducible IFN-γ immunity in both Vδ2+ γδT and MAIT cells @PhilippotQ Anne Puel Casanova Lab Jacinta Bustamante Science Immunology science.org/doi/10.1126/sc…

Today is International Day of Women and Girls In Science! To celebrate #WomenInScienceDay, we asked a few of our Broadies about the impact #WomenInScience make.

Our new manuscript by Hoang et al. Thanks to all who contributed especially our 5’leader Dr. Hoang!

Excited to share our latest article published in @plospathogens: journals.plos.org/plospathogens/… #plospathogensauthor

3 amazing papers just out nature, the kind worth giving up sleep for🦉 Spatial multi-omics human maps: -placenta: MIBI & DSP -intestine: CODEX & snRNAseq & snATACseq -kidney: Visium & scRNA & scATAC After sequencing single cells, we are now finally putting them back together🧵

Curious about microenvironment #pH in tissue #homeostasis and #inflammation? We discuss pH sensing&regulation in the framework of homeostatic&inflammatory circuits and why immune cells may be key. Kudos to Stephanie Hajjar Harvard Medical School Boston Children's Trends in Immunology Cell Press