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Excellent to hear that the FDA gave RMAT designation to DA-01 (Bemdaneprocel) following the promising 18-month data in 12 patients from the BlueRock-sponsored dopamine neuron cell therapy trial in advanced PD – see also article below and BR press release bit.ly/4c4QsMC

Excited to share our latest paper led by Rachel Glenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation. biorxiv.org/content/10.110…

Why do most dopamine neurons die shortly after transplantation and how can we fix it? Excited to see our story out at Cell. Congrats to Taewan Kim & SoYeon Koo Memorial Sloan Kettering Cancer Center and to all the other collaborators who made this work possible. cell.com/cell/fulltext/…

Cell Taewan Kim Lorenz Transient TNF-α inhibition overcomes a p53-dependent survival restriction in grafted dopamine neurons as a clinically relevant strategy to promote functional dopamine neuronal engraftment in Parkinson’s disease cell.com/cell/abstract/…

Excellent thread from So Yeon Koo on the paper (and also her thesis work 😊). Congrats!

How to trigger age-related features in hPSC neurons? In a CRISPR screen Nathalie Saurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell bit.ly/3XBxCsA

Super excited to see this study finally published after many years of work. Congrats to Nathalie Saurat for the heroic effort and to all the many amazing collaborators who made this work possible. Also big thanks to our funders particularly the JPB foundation, NIA and Aligning Science Across Parkinson’s.

Look, it’s the Lorenz lab past and present at #ISSCR2024. Getting together is another awesome part of attending this conference 🤩

Excellent thread from Shen-Ying Zhang on this new collaborative story, and for our lab one of the first studies to test run new hindbrain neuron protocol developed by @harschnitz

Excited to see the work published nature. Excellent summary in thread below. Big collaborative effort with Shen-Ying Zhang, Casanova Lab + many more. Special thanks to Yi-Hao Chan Lab, Zhiyong Liu, Paul Bastard and in my lab Noopur Khobrekar, Param Amin, Gabriele Ciceri & @harschnitz

Great postdoc opportunity if you are interested in developing next gen human PSC based cell therapies for brain repair here at MSK

Exciting opportunity for open tenure track positions in Developmental Biology & Stem Cell Biology Memorial Sloan Kettering Cancer Center (see Ad - go.nature.com/3yOv8gx). Deadline for applications is October 14, 2024 (facultysearch.ski.edu)

Congratulations to Dr. Shuibing Chen (Shuibing Chen) on her lab's new Cell Stem Cell paper! Her team developed vascularized macrophage-islet #organoids to study damage from infection. Read the article: bit.ly/4gqAcJ1 Learn more about her work 👇 bit.ly/3MuyPex

This was a great episode indeed. Congrats to Stefan Irion and Viviane Tabar

Excited to share the latest work from my lab and Emily Wong led by Daniel Medina Cano Tarek Veronika Petrova. We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells. Memorial Sloan Kettering Cancer Center Center for Stem Cell Biology at Sloan Kettering MSK ScienceEducation biorxiv.org/content/10.110…

📢 Join us! Developmental and stem cell biologists, checkout our tenure-track faculty position at Sloan Kettering. Apply by October 18. #DevBio #StemCell #hiringnow mskcc.org/research/ski/p…

👏 Congratulations to Dr. Deb Schrag, Chair of the MSK Department of Medicine, and Dr. Lorenz, Director of the Center for Stem Cell Biology at MSK, who were elected to the National Academy of Medicine, one of the highest honors bestowed upon scientists worldwide. Learn more: bit.ly/4fvwkoP

Congrats to @ZeltnerLab on their new paper. Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine science.org/doi/10.1126/sc…. It was exciting to see this story develop from way back.

Things I wish more people knew about doing science in the US (thread):

Dr. Viviane Tabar and Dr. Lorenz, physician-scientists at MSK, have developed a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients. Early results show the treatment is safe and may improve