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I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases Science Magazine! Raphael Ferreira @LeopoldParts Tom Ellis, george church @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

Want to play the Shuffle (on your favorite genome)? Watch this video from TDCC @genometdcc.bsky.social highlighting Sudarshan Pinglay et al. recent Science Magazine paper (link in comments). youtube.com/watch?v=rW8AFh…

We are hiring a person to join our team at the Seattle Hub for Synthetic Biology. Please share the word! Link to apply: alleninstitute.org/careers/jobs/?…

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

CAGT was fun! Thanks Carl de Boer Sudarshan Pinglay and the de Boer lab for organizing! Folks from Seattle, Oregon, and other places. Great community. Arman gave a usual super talk, and Sanchit and Dayag Sheykhkarimli won poster prizes☺️