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A new study in nature by the Song and Ming Labs labs, led by Yusha Sun, has mapped circuit integration of glioblastoma organoids transplants in mice and revealed how tumors persist and progress in patients' brains with the help of their own neural circuits. nature.com/articles/s4158…

Elegant and smart work by ⁦Song and Ming Labs⁩ ⁦Yusha Sun⁩ using trans-synaptic tracing and GBM mouse transplantation to study Brain-wide neuronal circuit connectome of human glioblastoma ⁦nature⁩ . Congrats to all team. nature.com/articles/s4158…

Our spatial multi-omics technology that co-profiles five modalities is now published in Nature Methods Nature Methods! Huge thanks to Marek Bartosovic, Mingyao Li, and my amazing team, including postdoc Pengfei_Guo and PhD student Liran Mao! nature.com/articles/s4159…

Our MR study suggests that GLP-1R activation improves mental health well-being and reduces risk of depression, bipolar disorder, and possibly substance use disorders. medrxiv.org/content/10.110… Thanks to Stephen Burgess C Mary Schooling

Thank you NASBS for the opportunity to present our work in collaboration with Song and Ming Labs developing skull base #chordoma #organoid models for personalized therapy. Yusha Sun Xin Wang Daniel Zhang Emily Pai, MD PhD Penn Neurosurgery Penn Medicine Chordoma Cancer Chordoma Foundation

Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨‍🦰🐵🐷🐭, revealing specialized features in humans. biorxiv.org/content/10.110…

1/ Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵 Open access link: nature.com/articles/s4158…

Congratulations to winners of The Brain Prize 2025! Professors Michelle Monje🎗️ 🟦, Stanford Medicine and HHMI Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience. They have revealed a profound connection between cancer and

A groundbreaking study published in Nature (Jan 2025) significantly expanded our understanding of GBM-neural circuit interaction. Sun et al. demonstrate that GBM integrates more extensively and rapidly into neural circuits than previously understood, making GBM not only a

How does the brain work? Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵

Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy hubs.li/Q03gkJxg0 Meghan Logun Yusha Sun Xin Wang Stephen Bagley and colleagues Collection highlight from Cell Stem Cell

Today in nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/corte… Paper link below👇

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Brothers Daniel & David Zhang followed similar paths in medicine & music at Penn Medicine & Penn Med Symphony Orchestra. A new philanthropic gift from Bruce Jay Gould,M.D. (Penn Cardiology) aims to recognize & amplify their efforts tinyurl.com/mr3x8fay

New from Song and Ming Labs (Song and Ming Labs)! The team reports a co-culture system employing patient-derived #glioblastoma #organoids and hiPSC-derived cholinergic neurons. 🧫🧠 📖 Read more: bit.ly/4jX8OTm

Delighted to share our most recent #CancerNeuroscience study, led by brilliant postdoctoral fellows @RDrexler and@ADrinnenberg, exploring the interactions between midbrain cholinergic neurons and diffuse midline glioma #DMG/#DIPG. 1/ cell.com/cell/fulltext/…

New research from Penn Medicine: Structural & functional cholinergic neuron-to-glioblastoma #synapses using an all-human cell co-culture platform of iPSC-derived neurons and #gliobastoma organoids. bit.ly/45YqECf ISSCR Cell Press Gairdner Foundation The Hospital for Sick Children (SickKids)