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Online in STAR Protocols: Dr. Koichi Iijima for assesses #Alzheimer's disease-related #amyloidβ toxicity in a transgenic fly model, using biochemical, histological, and behavioral approaches: hubs.li/H0T1Qp20

.#mitochondria are the powerhouse of the cell. Look at these small mito. (arrows) joining efforts to a bigger mitochondrion (circle). Mitochondria News #scicomm #organelles

First half-marathon training DONE! #SundayMotivation

Happy RNA day! In case you missed it, my latest blog post on imaging miRNA mediated translation repression & mRNA decay in the link below. You can find other RNA-related posts in my blog. greenfluorescentblog.wordpress.com/2021/07/25/ima…

Long-term depression (LTD) is a central form of synaptic plasticity. Much of the research on LTD has focused on mechanisms in neurons; a review by Caitlin Durkee, Paulo Kofuji, Marta Navarrete Llinás & AraqueLab examines the involvement of #Astrocytes in LTD: cell.com/trends/neurosc…

Scientists have discovered how a genetic mutation may contribute to #ParkinsonsDisease by disrupting #endocytosis, the process by which cells take in outside materials such as proteins. fcld.ly/t07y0i9 @SciSignal

Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1, say Lu Song, @xsharon18 and Randy Schekman UC Berkeley. bit.ly/2VfUAaj #Neuroscience #Trafficking #StemCells

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis dlvr.it/S4vcRn

Two new studies in mice show that the brain is an immunologically distinct organ that is surrounded by its own cadre of immune cells. Read more: fcld.ly/v463r2t #SciencePerspective

doi.org/10.1038/s41556…

Amazing brain specimen from Jayaram Chandrashekar and the MouseLight team, cleared and imaged on our new hybrid light-sheet system. Updated preprint with more details and datasets coming soon!

First time being a session chair…makes me feel passionate to jump out of my comfort zone and admire the broadness of science. Get rid of the box and fight the fear.

Protein synthesis in synaptic mitochondria? What neurodev diseases may have defects on this type protein synthesis? Learn more in our SfN Journals paper. jneurosci.org/content/41/31/… Mitochondria News MitoMedicine #mitochondria #jneuroscience kaela #22q11 #Schizophrenia #autism

I am thrilled to share our work published in Neuron Neuron on transcellular oligodendrocyte-to-axon signaling that enhances axonal mitochondrial bioenergetics. Congrats to Kelly and Ning and all coauthors. authors.elsevier.com/a/1djN83BtfGzk… The lab is recruiting postdoc fellows.

We are recruiting postdocs to study axonal energetic metabolism with a special interest in cross-talk between energy sensing and axonal maintenance of mitochondria and lysosomes in neurodegeneration, regeneration, and ageing. Details: research.ninds.nih.gov/sheng-lab/post…. Please R/T.

‘Energy matters: presynaptic metabolism and the maintenance of synaptic transmission’, a Review by Sunan Li & Zu-Hang Sheng go.nature.com/3kJ964i Sunan Li Zu-Hang Sheng @NINDSnews

Delighted to see our review going online! In this energy-focused review, we discuss the challenges that neurons face in preserving presynaptic energy metabolism to sustain synaptic efficacy and plasticity, an emerging field relevant to a range of neurological disorders.

Delighted to share our review led by Sunan Li and invited by co-editors Inna Slutsky and RH Swerdlow. We overview recent advances in how oligodendrocytes support axonal energy metabolism in health and neurological disorders. authors.elsevier.com/a/1gsm73Q9h2Ee…

Tools won't replace you. Someone using them may! Here are the essential research tools you should learn in 2023 (part 1). These tools will save you 100s of hours. Which ones are your favorite?

Proteasome cap particle regulates synapses science.org/doi/10.1126/sc…