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🚨 Save the date! The 2025 St. Louis Translational Pain Research Forum returns Sept. 26–27. Join leading minds across #STL & the Midwest coming together to advance pain research. Learn more & register: stl-tprf2023.my.canva.site/stl-tprf2025 Institute for Translational Neuroscience WashU Pain Center University of Health Sciences and Pharmacy in STL #STLTPRF

I was asked what America and Princeton University mean to me. With the University’s help we made a very short video, where I talk about Princeton and why all of our academic enterprises are so important to the US and to the world. As you can see, this is very personal for me.

For those interested in our peripheral DREADD here is the source of the ligand: hellobio.com/fch-2996413.ht…

The 2025 GRC on Cannabinoid Function in the CNS: Cannabinoid Neurobiology: Bridging Basic Science, Big Data, Biomarkers and Bedside Applications Across the Lifespan final program is here! Spots are going fast! Register soon for trainee talks! RT please! grc.org/cannabinoid-fu…

I have trained many folks from mainland China. They were mostly great, enthusiastic, well trained, and knowledgeable. The vast majority would like to become US citizens and generally did not care for the various “political issues “ .

Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! biorxiv.org/content/biorxi…

Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor biorxiv.org/content/10.110… #biorxiv_pharma

Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving Gi activation and how its modulated by different ligands! biorxiv.org/content/10.110…

Organic chemist Robert A. Holton dies at 81 His semisynthetic route to Taxol made the lifesaving cancer drug available in commercial quantities. cen.acs.org/people/obituar…

Discovery of a functionally selective serotonin receptor (5-HT1AR) agonist for the treatment of pain | Science Advances science.org/doi/10.1126/sc…

Want to present a poster at the 2025 St. Louis Translational Pain Research Forum? Posters are due Sept. 5. Learn more: stl-tprf2023.my.canva.site/stl-tprf2025 #STLTPRF

Latest opioid paper from our end led by Balazs Varga Synthesis and Pharmacology of a Morphinan-Derived Dual Mu–Kappa Opioid Receptor Agonist Analgesic | ACS Chemical Neuroscience pubs.acs.org/doi/10.1021/ac…

Our latest review on GPCR-lipid interactions is out at Curr. Opin. in Struct. Biol. sciencedirect.com/science/articl… Congratulations to postdoc Dr. Greeshma Jain!

Congratulations to Team Carbamorphine, led by Sota, along with our collaborators from the Majumdar and McLaughlin groups on the publication of our work in PNAS! pnas.org/doi/10.1073/pn…

Check out this article from College of Chemistry highlighting our carbamorphine work! chemistry.berkeley.edu/news/carbamorp…

In a study published this week in PNASNews, Dr. Jay McLaughlin and a team of scientists demonstrate how a single-atom swap in morphine’s structure leads to carbamorphine, a new compound with pain relief benefits but fewer side effects. pnas.org/doi/10.1073/pn…

Check out this article in The Daily Californian highlighting our recently published carbamorphine work! dailycal.org/news/campus/re…

USASP is currently participating in virtual Hill visits to educate congressional staff about the importance of NIH funding for pain research. Want to help? Reach out to your representatives and share why pain research matters to you. Learn more here ⬇

The Fakira Lab at the Cooper Medical School of Rowan University is seeking a highly motivated postdoctoral fellow to join our R01-funded research project focused on neuropeptide receptor function in the context of pain and addiction.

Highly recommended 👇