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CVD is the leading cause of 🌏 morbidity & mortality. Many are caused by damaging DNA 🧬 variants and require lifelong treatments that mitigate but do not cure disease. This advisory looks at gene therapies to treat CVD. ✍🏼: Yuri Kim @APLandstrom Svati Shah Joseph C Wu, MD, PhD

Very excited to share our AHA Science Advisory where we discuss current promises and limitations of gene therapy in CVD. It was such an honor to work with @APLandstrom Svati Shah Joseph C Wu, MD, PhD, Kricket, AHA Science American Heart Association and Circulation Brigham and Women’s Cardiovascular Life Science Brigham and Women's Hospital #GeneTherapy

New science advisory on Gene Therapy in CVD👇👇thanks to Paul St Laurent, DNP, RN 🏳️‍🌈 Yuri Kim @APLandstrom Svati Shah Joseph C Wu, MD, PhD and the fantastic Kricket Seidman

NEW AHA Science Scientific Statement from the Inaugural Primary Care Science Committee !! "Role of Primary Care in Achieving Life's Essential 8" Circ: CQO Key takeaways ✅here: newsroom.heart.org/news/primary-c… Article 📰 here: ahajournals.org/doi/10.1161/HC…

Key programming for women in cardiology at #AHA24 Thanks to the developers and participants of these excellent sessions. Monika Sanghavi MD, FACC Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Erin D. Michos, M.D. Dr Roxana Mehran Jo Chikwe Svati Shah AHA Science Dr Anastasia Mihailidou FAHA FCSANZ FESC

#AHA24 Early Career Spotlight on some amazing young and promising talent in the space of CV medicine. From Software to Hemodynamics, everything was represented. Thanks for AHA for funding this work. The future is bright. AHA Science AHAMeetings Emily Lau, MD, MPH Jessica B. Briscoe, MD

Excited to be at #AHA24 and share the excellent work of our trainees, collaborators, and friends!

#AHA24 Genomics and Precision Medicine Council American Heart Association on training in #CardioGenomics Thrilled to see major efforts in this direction @APLandstrom Anwar Chahal MD PhD MRCP Dan M Roden MD Svati Shah Iftikhar J. Kullo Michael J. Ackerman MD,PhD ahajournals.org/doi/abs/10.116…

Congratulations, great work Senthil Selvaraj, MD, MS, MA! A great step towards use of exogenous ketone therapy in HF

SGLT2i demonstrate common (fatty acid) and distinct (ketogenic) metabolic signatures across the LVEF spectrum Senthil Selvaraj, MD, MS, MA Svati Shah Mikhail Kosiborod Duke Heart Saint Luke's Mid America Heart Institute Sanjiv J. Shah, MD @bborlaugmd ahajournals.org/doi/full/10.11…

Our 4th annual Genomics Scientific Retreat is only 3 weeks away! duke.is/PCG-retreat

Free nationwide genetic carrier screening of 10K reproductive couples during current or planned pregnancy offered during carrier screening for 1300 genes in Australia reported. 1 in 50 with a positive result & influenced pregnancy plans nejm.org/doi/full/10.10… NEJM

This Cell paper making the most of the #proteomics resource of the UK Biobank is a great Sunday read📖❗️ 🔗cell.com/cell/fulltext/… It highlights at scale the areas, where proteomics could provide meaningful insights: 🧵

Awesome talk from the incredible Sara Adelman Coles, MD at Duke University School of Medicine genomics symposium. Cool work w/ a homegrown pipeline for WGS to identify causative genetic variants in families with arrhythmias. Sara is a rising ⭐️ in EP and arrhythmia genetics 🧬, keep an 👁️ out for her!

Fantastic talk from super ⭐️ Jessica Regan at Duke University School of Medicine Precision Genomics Collaboratory retreat, 2nd place for best oral presentation! Metabolic pathways and snRNAseq for epicardial and pericoronary fat

1/ 🌟 New treatment paradigm in heart failure! The REMOTE-HF study explored BAY 2413555, a novel M2 receptor modulator aiming to enhance parasympathetic activity in HF patients. Findings show promise but come with some caveats nature.com/articles/s4159…

CPET is essential for comprehensive care of patients w/ CHD, offering valuable prognostic insights & assisting in clinical decision-making across various congenital heart conditions, thereby significantly ⬆️patient management & outcomes. ✍🏼 Adam_Powell Dave White Barbara Cifra, MD 🫀🇮🇹🇨🇦

📰A professional update 🔥 My recent boss, mentor, and friend Mikhail Kosiborod recently left Saint Luke's Mid America Heart Institute and Saint Luke's to lead late-stage CVRM development for AstraZeneca. As a result, I am assuming a number of vacated leadership roles, including: Executive Director,

Should there be systematic genetic screening for the most common variants of TTR amyloidosis? This piece explores the gaps & considerations of implementing V142I variant screening programs🧬 🔗bit.ly/4jf8T5D

Congratulations Dr. Prashant Rao! So well deserved!!