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Interested in CRISPRi in iPSCs and derived cell types? Together with Allen Institute & WardLab, we generated a highly characterized, publicly available line. Big thanks to Kun Leng, Nina Draeger, Olivia Teter, Syd Sattler & others in the @kampmannlab! tinyurl.com/y6fgqvnj

Happy #InternationalWomenInScienceDay! Shoutout to the fantastic women scientists of the @kampmannlab, and everywhere else.

A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states biorxiv.org/cgi/content/sh… #biorxiv_neursci

Thrilled to share our preprint "A CRISPRi/a platform in iPSC-derived #microglia uncovers regulators of disease states"!Collaboration with Gan Lab, led by Kampmann Lab Nina Draeger & Syd Sattler and Gan Lab Cindy Huang 1/3 biorxiv.org/content/10.110…

Excited to share our new preprint! In research led by Brendan Rooney & Kun Leng in the Kampmann Lab, we found that in inflammatory astrocytes, mTOR signaling causes lysosomes to be remodeled, deacidified and exocytosed, causing neurotoxicity. (1/2) biorxiv.org/content/10.110…

Big thanks to all additional contributors: Kampmann Lab Indigo Rose, Saeed Fathi; Chan Zuckerberg Biohub Network Frank McCarthy, Josh Elias, Sophie Bax, Manuel Leonetti; @UCSF_Biochem Kari Herrington; UCSF MAC Marcus Chin, @aimee_kao. … and here’s an astrocyte caught in the act: (2/2)

Thrilled to have our preprint out! Lysosomes do really interesting things in inflammatory reactive astrocytes—check it out!

It’s out! Our Nature Neuroscience paper introducing an iPSC-Microglia protocol and screening platform that identifies modulators of microglia functions and states: “A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states.” nature.com/articles/s4159… 🧵(1/15)

Learning to control microglia using CRISPR Thank you NIH for supporting our work (first author Nina Draeger, collaboration with Gan Lab) and for this write-up! nih.gov/news-events/ni…

Honored to be chosen to hold the Brewer Fellowship which supports research on model organisms. In the Abitua lab we study annual killifish!

Our lab manager Laura Stump test drives our new LSM 900. #FluorescenceFriday

Absolutely thrilled to share mine and Troy McDiarmid’s work describing the development of a multiplexed, scalable CRISPRa cell type-specific screening framework that is able to identify…(1/n) biorxiv.org/content/10.110…

Beth is simply the best scientist and molecular biologist i have ever known. still amazed by her ability to profile so many cells even have watched the process over the years.

Incredibly honored to have received a Curci Fellowship! Shout out to my dept and lab Phil Abitua 🧬 for all of the support :)

education.uwmedicine.org/blog/2024/03/2…

It's #MicroscopyMonday, so let's take a look into the 🔬! This colorful confocal image of squid embryo (Dorytheuthis pealei) was taken during a MBL Embryology Course. Credit: Juliana Roscito (University of Sao Paulo), 2012 Embryology Course

Excited to see our spotlight piece out in Development! We highlight how scRNAseq and CRISPR gene editing are revealing incredible cell type evolution stories across the tree of life!

I am excited to share our work in which we conducted a CRISPRi-based screen to assess 102 Autism Spectrum Disorder (ASD) risk genes in microglial uptake of synaptic material! (1/7) biorxiv.org/content/10.110…

Proud to be a childless cat lady. My car is #brat too.

New blog post in our "Emerging, Uncommon, and Non-model Organisms" series! Huge thanks to Syd Sattler for contributing on her work with killifish ascb.org/science-news/e…