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One of the most illuminating medicinal chemistry papers I have ever read: 'Biotin's Lessons in Drug Design' (PMID 34784474) by Darryl B McConnell. I promised myself never to forget those neglected non-classical CH–O hydrogen bonds now. If my resolution allows, of course! ACS Publications Bio & Med Chem Content

Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? Google DeepMind

Neither Magdalena Skipper (editor of nature) nor the handling editor would answer my emails about my concerns. I was not allowed to see any response to the reviews by the AlphaFold3 authors, so I don't know what they think either. Extremely unusual and very disappointing

Good context from Derek re: AlphaFold 3, to which I’d add: remember that the training set is king. AlphaFold is built on decades of deposited structural data, and there’s nothing else of remotely comparable quality for modeling other biological phenomena. science.org/content/blog-p…

So yes, you CAN screenshot a scan of a 1974 paper and get a 30Å resolution reconstruction in an hour using e.g. RELION that surpasses anything they could get back in the day. It's been 50 years, so perhaps not too surprising, but kind of fun.

Absolutely delighted to share this work on the conserved interaction between Twisted gastrulation and BMPs! Congratulations to my co-first authors Tomas Tomas Malinauskas and Amalie, and the entire team! Take a look here: nature.com/articles/s4146…

Authors from The Ashe lab, @BaldockLab including Tomas Malinauskas and Gareth Moore report structures of TWSG1 in complex with a BMP ligand and show how TWSG1 inhibits signaling. nature.com/articles/s4146…

I'm incredibly grateful to BBS and the organizers for a fantastic biennial meeting at Swansea University Bay Campus with its stunning coastal views! Looking forward to the next one. #BBS2024

One great thing about Oxford: lectures by the smartest minds. This week’s highlight: Prof. Christopher Garcia (Stanford) on TCRs — from 90s crystal structures to deorphanization & immuno-oncology. Thanks to Ricardo A. Fernandes for organizing!