Delighted to share our latest work on RNA acetylation (ac4C) now out @nature. A wonderful interdisciplinary journey in collaboration with the chemical @doc_jlmeier and structural Shalev-Benami labs, spearheaded by the one and only Aldema Sas-Chen. nature.com/articles/s4158…

How TF differentiate promoters invivo but show promiscuous binding invitro? -DBD r not enough for specificity -IDRs play a role in binding-selection -IDRs outside DBD r reqrd & sufficient for specific TF-promoter interactions -IDR specificity is conserved cell.com/molecular-cell…

Glad to share my paper with Offir Lupo Barkai Lab is published now Genome Research! How does transcriptional regulation change between closely-related species? Do changes in transcript abundance must involve changes in dynamic regulation? …nome-cshlp-org.ezproxy.weizmann.ac.il/content/early/…

🥳🔥 Excited to finally share the latest work from my Ph.D. studies @barkailab: we set out to understand how and why transcription limit cellular growth. g3journal.org/content/early/… Together with the amazing and twitterless #giladyaakov and #moshekafri, Genetics Society of America (1/7)

For those of you who found our paper too long to read 😉 – here’s a wonderfully written spotlight that captures the essence of our work. Thank you U.S. Sandra, Arushi Shukla and Ullas Kolthur. Tamar Jana Barkai Lab Trends in Genetics Molecular Cell cell.com/trends/genetic…

🥳📢 In the truly latest work from my Ph.D., lead by mirar & einat zalckvar (#SchuldinerLab), we use in-cell competition to uncover peroxisomal targeting priorities! We gradually burdened the targeting machinery while watching for left-out proteins doi.org/10.1073/pnas.1…

Take a look at our new Trends in Genetics opinion piece! Focusing on speed–specificity trade-offs in the transcription factors search for their genomic binding sites. Barkai Lab Tamar Jana Naama Barkai cell.com/trends/genetic…

Our Trends in Genetics opinion article is out! Sagie Brodsky Naama Barkai and I discuss mechanisms through which transcription factors detect their binding sites within large genomes. We focus on two key properties of this search: Specificity and speed. Barkai Lab cell.com/trends/genetic…

Look at our beautiful Trends in Genetics cover! Sagie Brodsky Thanks to Neta Hadar and Danasaurus Rex

Measurement of histone replacement dynamics with genetically encoded exchange timers in yeast go.nature.com/3AHuTzI

An amazing work by Gilad Yaacov FJonas from our lab! Congrats 👏🎉

Order through disorder - we wrote a review about the role of IDRs in TF binding specificity Tamar Jana Barkai Lab Current Opinion/Research in Structural Biology authors.elsevier.com/c/1dRdD,LqArIa…

Excited to share our newest preprint by Tamar Gera FJonas & Roye More: Evolution of binding preferences among whole-genome duplicated transcription factors biorxiv.org/content/10.110… Ever wondered how the transcriptional network evolves? Read more to find out! (1/7)

Come join us :)

🥳🎉We are delighted to share our new paper that deciphers the complementary strategies by DNA binding domains (DBDs) and IDRs in directing transcription factor (TF) target specificity. 🎉🥳 cell.com/molecular-cell… Divya Krishna Kumar FJonas naama barkai

Check out our new paper: “Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars” published Nucleic Acids Res. The work of Vladimir Mindel and Sagie Brodsky. academic.oup.com/nar/advance-ar…

Exciting news! Our latest paper "Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences", led by Michal Chappleboim is now out in Nucleic Acids Res. Check out the highlights below. doi.org/10.1093/nar/gk…

(1/13) Exciting findings from our latest study, now published in Nucleic Acids Res as a breakthrough article! academic.oup.com/nar/advance-ar…

Beautiful work by beautiful people!