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We can computationally design de novo (mini)binders, what are the best scientists using it for? Scientists have now generated close to 100,000 de novo designs using BindCraft, RFdiffusion, and others on Tamarind Bio, here are the highlights: 1/🧵

Nice reference sheet to AI models for proteins: tamarind.bio/blog/a-compreh…

Excited to announce our new product: AI Protein Design Copilot Tamarind Bio has been the leading provider to use the top AI tools in computational protein engineering. Today we announce a completely new way to interface with computational molecular design. Available now!

Will AI-designed proteins break biologics patents? If your IP strategy still relies on “≥80 % sequence identity,” it might be time for a rethink. Thread👇 Tools like ProteinMPNN from the Baker Lab, take an existing e.g. AbAg complex or enzyme and can replace substantial parts

I haven’t had a chance to test this AI tool for protein engineering yet, but it looks very interesting! Deniz, you’re also very welcome to our community.

A new best structure prediction protocol! Use it on Tamarind Bio today: app[dot]tamarind[dot]bio Thread 👇 On the comprehensive FoldBench benchmark, IntFold’s performance is comparable to AlphaFold 3 and significantly exceeds other contemporary models (Boltz-1, 2, Chai-1,

Are mini proteins the new antibodies? Mini proteins are highly stable, easy to manufacture, and very quick to design thanks to recent AI methods. Unlike mAbs, there is a large body of structural data to train machine learning models on to generate de novo mini protein binders.

When are AI-designed drugs making it to patients? No AI-designed medicine is on pharmacy shelves yet, but the first wave of molecules now in Phase 2/early Phase 3 (chiefly rentosertib for IPF). Here's where we are, a thread👇

How Genentech/Prescient Design use AI to design 3-100x better antibodies Genentech uses lab in a loop as an iterative approach for designing antibodies by marrying generative machine learning models, property predictors and data from in vitro experimentation. Thread👇 The

How Can We Computationally Solubilize Membrane Proteins? Thread 👇 Membrane proteins are not members of the soluble proteome, i.e. their structure cannot be maintained outside of the membrane/in solution. Traditionally, the solubilization would be done using detergent, but this

A warning that proteins are highly dynamic molecules 1/🧵 Unlike what we get from AlphaFold, proteins don't exist as single, static molecules in the body. Structure prediction methods, while highly valuable, provide only a single moment in a protein's existence. There are

Should we stop humanizing antibodies? Recombinant DNA, and mAb production started the antibody engineering revolution, followed by chimerics and humanization via grafting antigen-binding regions to human frameworks. 1/🧵 Two decades apart, Clark (2000) and Getts et al.