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In this study, we show oligoTRAFTAC-mediated degradation of two oncogenic transcription factors: c-Myc and brachyury. Degradation of brachyury was achieved in both chordoma cell lines as well as in vivo zebrafish model. Congrats to Kusal Samarasinghe and the team!!!

Brachyury promotes proliferation and migration of hepatocellular carcinoma via facilitating the transcription of NCAPG2 dlvr.it/SYbP4q

Heading to #GfE2022 on a way to early train 🚂😴 If you’re interested in vertebrate axis elongation, notochord function or enhancer synergism in the #Brachyury T locus, find me today at poster #43.

An ancestral Wnt–Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes rdcu.be/cZWhD

I am happy to share our new paper with our great collaborator lab of @InaArnone on comparative Brachyury target gene screen using genome-wide ChIP-seq in @Nematostella and @Strongylocentrotus is out: Nat Ecol Evol. 2022 Nov 17. doi: 10.1038/s41559-022-01905-w.

Knockdown of Brachyury Suppresses Breast Cancer Cell Proliferation and Migration via Targeting E2F3 pubmed.ncbi.nlm.nih.gov/36457717/

#FunFactWednesdays 👉 100 years ago, one of the first ever genetic screens for vertebrate developmental mutants was initiated by Russian Empire scientist Nadine Dobrovolskaïa-Zavadskaïa at Institut Pasteur in Paris 1/8

#WorldCancerDay, is a time to highlight international efforts to prevent, detect, and treat #cancer. Read how a #NIH research team led by @NCIResearchCtr Dr. Claudia Palena has contributed to the development of brachyury-based #cancervaccines: bit.ly/3wGEgPl

Conserved enhancer logic controls the notochord expression of vertebrate Brachyury biorxiv.org/cgi/content/sh… #bioRxiv

Our latest preprint on #notochord enhancers is now online 👀👀👀👀 It’s a short one, but still here’s a summary thread👇 biorxiv.org/content/10.110… 1/13

Never-ending story of Brachyury: From short-tailed mice to tailless primates sciencedirect.com/science/articl…

Funding opportunity up to $300k for research on the TBXT/brachyury regulatory network. chordomafoundation.org/researchers/#o…

First published chemical tool for depleting brachyury (TBXT) in cells is a major step forward in pursuing therapies against this target in chordoma and other cancers. Thanks for this important contribution ⁦Craig Crews⁩ &team + ⁦The Mark Foundation for Cancer Research⁩! pubmed.ncbi.nlm.nih.gov/38348945/

A true curiosity-driven journey, fulfilling one of my childhood dreams! The tail loss marks a pivotal evolutionary step towards humans and apes. But how did it happen? rdcu.be/dzTba Itai Yanai Jef Boeke

Today is a very special day its… a brand new #ArticleinPress! Brachyury Promotes Extracellular Matrix Synthesis through Transcriptional Regulation of Smad3 in Nucleus Pulposus (Yanzhang Xia et al.): ow.ly/WRy650RaFsZ #Extracellular #Matrix #Nucleus

Announcing TBXT (brachyury) protein available to enable drug discovery! Building on a Structural Genomics Consortium (SGC) protocol, we're now able to supply protein to labs or companies to expedite experiments on this target. DM or email us at [email protected] to request or learn more. 1/4

As background, TBXT (brachyury) is a promising emerging oncology target implicated in number of cancers with minimal expression in normal tissue: pubmed.ncbi.nlm.nih.gov/32209441/ The TBXT Target Enabling Package from Structural Genomics Consortium (SGC) is available here: thesgc.org/tep/tbxt 4/4

Results in this new preprint provide a major leg up for efforts to drug brachyury: biorxiv.org/content/10.110… Some highlights: 1. Crystal structure of WT and G177D brachyury in complex with DNA 2. Crystallographic fragment screening of brachyury 3. Identification of numerous