Numerous studies have revealed that the gut microbiota may affect learning and memory. Here scientists update the roles of gut microbiota in the regulation of hippocampal plasticity, inflammation and hippocampus-dependent behaviors ow.ly/RMwp30rxeuz

Les #FeuxDeForet marquent régulièrement l’actualité. Le #changementclimatique, l’intensification et l’étalement des implantations humaines ont multiplié les risques d’#incendies, faisant peser de nouvelles menaces sur les #forêts et les habitants Dossier👉url.inrae.fr/3rV5COL

B. lactis lowers TRUC colitis by lowering K pneumoniae and P. mirabilis levels and caecal pH #MFH2010

Macpherson: established a reversible colonisation model with mutant of E. coli K12 (Alanine deficient) #mfh2010

live bacteria are required for IgA secretion #mfh2010

accumulation of Treg in the colon seems to be due to gram+, sporulating bacterial fraction of the intestinal microbiota #mfh2010

gnotobiotic mice carrying 46 Clostridium species accumulate Treg in their lamina propria #mfh2010

clostridium abundant mice showed increase in Treg => IL10 => resistance to colitis induction by DSS #mfh2010

Dore: Does one of the 46 clostridia species do the job alone? response: they tried 3 species but the induction of Treg was moderate.#mfh2010

P. Calder: Evaluation of immune function in human trials #mfh2010

B. Lemaitre: Drosophila as model for host microbiota interaction #mfh2010

tolerance to intestinal microbiota in drosophila is a combination of neg. regulation of systemic response #mfh2010

...and compartimetation of antibacterial response #mfh2010

intestinal epithelial cell renewal induced by oxidative damage in drosophila ( for example JAK/STAT pathway) #mfh2010

drosophila pathogen P. entomophila blocks the epithelial renewal in the intestine at a translational level #mfh2010

PolySacharideA (PSA) from B. fragilis reduces TNBS induced colites via mediation of Treg expansion #mfh2010

PSA has a protective and therapeutic effect on TNBS colitis #mfh2010

PSA induces IL-10 production in Treg=> reduction IL17 production => reduction of colitis #mfh2010

Type VI secretion system of Helicobacter hepaticus acts as a anti-inflammatory balance system during colonisation #mfh2010

Unrest at Home: Perturbation and Stability in the Human Microbiota by David A Relman #mfh2010