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2/2 We're writing up a detailed bioRxiv manuscript now, but we wanted to post our protocol for other labs to test out right away. #BEARmix🐻 is not yet FDA EUA-approved but we're exploring that possibility. Thanks to our COVID team and leads Thomas Graham @DarzacqClaire& Gina!🐻🐻🐻

(1/n) excited to share our new preprint: We visualize and track a CTCF/cohesin loop live using super-res live-cell imaging. CTCF/cohesin loop is rare (~3-6.5% of time) and very dynamic (~10-30 min lifetime), ruling out models of TADs as stable loops. biorxiv.org/content/10.110…

Introducing PAPA (proximity-assisted photoactivation), a new approach to detect molecular interactions in live-cell single-molecule imaging. Thomas Graham Xavier Darzacq biorxiv.org/content/10.110…

Local PhD says: Do this every day to detect protein-protein interactions using photoactivation. (Figure 6 will shock you!) 🍎🍐🥦🍊🥑 elifesciences.org/articles/76870 Thomas Graham, Jack Ferrie, Gina Dailey, Xavier Darzacq, Tjian + Darzacq Group

New review out today Molecular Cell by the TAG team Jonathan P. Karr and Jack Ferrie - here they examine the expanse of IDRs in eukaryotic TFs and review how these non-conserved regions may lend to fundamentally different regulatory mechanisms than well-structured TFs in bacteria.

New preprint from the lab describing the structural role of Lig4 in end synapsis during NHEJ. Using 2 and 3-color smFRET approaches, we show that end binding by Lig4 is essential for formation of the short-range synaptic complex. biorxiv.org/content/10.110…