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In the depths of the Mongolian Desert today, we found suǒ yáng 锁阳 (Cynomorium)! This extraordinary plant is much celebrated here as a medicinal plant and used to treat stomach complaints. A leafless parasite, it steals its food from the roots of desert shrubs. It is such a

Pfs48/45 nanobodies block transmission 🦟 Pfs48/45 Nb-Fc reduce oocysts 💎 Structure of transmission-blocking Nb with Pfs48/45 👐🏽 Bispecific Nb-Fc targeting Pfs230 and Pfs48/45 🧑🏻‍🔬 PhD student Frankie Lyons 1st Author 🥳 Please repost & happy reading! biorxiv.org/content/10.110…

Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife: elifesciences.org/articles/101322

📢 New paper announcement! Nanobody-mediated targeting of Plasmodium falciparum PfPIMMS43 can block malaria transmission in mosquitoes. Read the paper today in Nature Communications: bit.ly/44Ln7GA Congratulations to the team! 🎉

Duke-NUS is hiring professors at all ranks! careers.nus.edu.sg/job/Assistant-…

Tweeps, please spread the word. We're still looking at recruiting a structural biologist (any level) Sophien Kamoun to study plant-pathogen protein complexes especially in the context of coevolution. Direct inquiries welcome. Please include a cover letter. Applicant from US

Our sapphire tower (Puya alpestris) blossomed today for the first time in five years. It is native to the Chilean Andes where its flowers - an improbable shade of blue - are visited by birds.

The Cumming Global Centre Doherty Institute University of Melbourne is recruiting global research leaders to accelerate pandemic therapeutic development. 7-year research packages. Real impact. Real support. Apply now: go.unimelb.edu.au/4trp

🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery. For more information and to apply 👇 wehi.edu.au/careers/make-y…

In eLife - the journal: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei doi.org/10.7554/eLife.…. Out today. If you are at @biomalpar then happy to show the poster on it.

Meet Sophien Kamoun, one of our plenary speaker! Dr. Kamoun The Sainsbury Laboratory studies plant-pathogen coevolution and how it impacts mechanisms of virulence and immunity. Register for #CFN25 to hear Dr Kamoun speak in August.

Science road trip to discuss chytrid, frogs + effectors 🐸 Fun visit with Megan Outram to learn all things chytrid from Lee Berger & Lee Skerratt - very interesting links between plant fungal pathogens and chytrid - excited to get this program going ourANU #chytrid #plants

Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Fully and generously funded by a donation from the Kyner-Field family with full fees at overseas level. Join us?? bioch.ox.ac.uk/studentships

Remember the world record diamond model from #IUCr2023? It's now part of 750 Crystal Explorer Kits we're giving away FREE to *primary* schools in regional and remote Australia and NZ. Details and order form here: braggyourpattern.com/crystal-explor…. #ozchem #elementsets #outreach #SciComm

For those already using Boltz-2 affinity prediction, we realized that there was a bit of confusion around the different outputs from the models and in what contexts each should be used. We've added more details in the docs. A summary below.

Boltz-2 just dropped: open-source AI that predicts both protein complex folds ✚ binding affinities in one shot 🚀 This is a win for protein AI, but let's not forget MSAs, the bioinformatics backbone many structure models lean on.

Our latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!

🧬 Boltz-2: A new era in AI-powered drug discovery. MIT & Recursion just released Boltz-2 — an open-source biomolecular model predicting structure and affinity in one go. 🧵👇

NEWS: Professor Ana Domingos (Department of Physiology Anatomy & Genetics (DPAG)) and Professor Matt Higgins (Department of Biochemistry at Oxford University) have been elected to the EMBO Membership in recognition of their outstanding achievements. Congratulations! 🎉 medsci.ox.ac.uk/news/oxford-re…

Wonderful Friday for a PhD thesis submission Jaison Dsa WEHI (Walter and Eliza Hall Institute) 🩸Stabilized variants for sero-diagnostics 🦙Nanobodies against Plasmodium adhesins (watch this space) Been incredible working with Jaison across the years and sharing co-supervision with Phillip Pymm