🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins pnas.org/content/119/3/…

Want to join us in the Department of Biochemistry at Oxford? We are currently recruiting an Associate Professor! Come be part of a thriving community of folks interested in Chromosome and RNA biology. Link to job advert below. Please retweet! my.corehr.com/pls/uoxrecruit…

📢April 5th-3rd Chromatin Club Miami Sylvester Comprehensive Cancer Center and Active Motif! Our terrific speakers: Joanna Wysocka Stanford Medicine Peter Lewis Peter Lewis UW–Madison Erietta Stelekati Sylvester Comprehensive Cancer Center Lu Chen Lu Chen Fox Chase Cancer Center Free👇 activemotif.com/chromatin-club…

Great work and read for polycomb/epigenetic peeps Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals | Nature Genetics nature.com/articles/s4158…

FASEB Catalyst Conference on Protein Arginine Methylation in Physiology and Disease February 15, 2023, 10 am–2:30 pm (ET) Registration is Free! More information here: faseb.org/meetings-and-e… Please RT

How is the embryonic chromatin activated? science.org/doi/10.1126/sc… I am happy to share our findings on how Nr5a2 acts as a pioneer factor during the murine zygotic genome activation Science Magazine #ScienceResearch Together with Wataru Kobayashi, Siwat Chad & Imre Gáspár.

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1 | nature.com/articles/s4158… | Nature Genetics | #chromatin #epigenome #3dgenome

I’m sad to learn about the passing of my dear friend, mentor, and colleague C. David Allis. The chromatin community will miss you immeasurably.

FREE, online FASEB conference on #Protein #Arginine #Methylation in Physiology and Disease, 2/15. Info & Reg: bit.ly/3wtqPCw Organizers: Wei Xu, PhD McArdle Laboratory & Peter Lewis, Lewis Lab, University of Wisconsin #methylation #proteins #lysine #PRMTs

I would like to share with you our new work on the identification of the first bona fide 'reader' of #histone H3K79 methylation, which has been a mystery since the discovery of this modification in 2002. science.org/doi/10.1126/sc… today online in Science Magazine

Excited to share in Nature Chemical Biology our work revealing a repressive histone methylation ceiling using drug addiction mutations, & how we can exploit it as a vulnerability in EZH2-mut lymphoma. Big thanks to Hui Si, Ally Freedy, Liau Lab team, & Stephen Kissler! nature.com/articles/s4158…

Check out the News and Views on the Liau paper by Tyler Reich and Peter Lewis, Lewis Lab. Free to read link at rdcu.be/c8vZp

Hello grad program community! I'm interested to learn about your experiences with graduate program interviews and recruiting this year. Were they conducted in-person together, or were the interviews held online followed by in-person recruiting? Please share your insights! :)

How conserved is this AS event? Evolutionary analysis shows that SUZ12 exon 4 skipping appeared in placental mammals while it behaves as a constitutive exon (always included) in all other vertebrates REGARDLESS of the tissue/cell type! 🐘🐮🐭🏃 (skipping) 🦈🐠🐔🦘(inclusion) 3/9

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons nature nature.com/articles/s4158…

The HuSH complex silences retrotransposons in vertebrates. Our latest manuscript introduces HuSH2 and delves into the fascinating interplay of two paralogous HuSH complexes in governing LINE-1 silencing. Credits to Zena Jensvold and Anna Christenson. doi.org/10.1101/2023.1….

The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. nature.com/articles/s4146…

Today in nature we share our back-to-back stories with Ning Zheng revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

Happy Polycomb Day (3/27)! Today we celebrate H3K27me3- Polycomb’s quiet mark of repression, where gene silencing is not neglect, but a deliberate act of identity.

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. tinyurl.com/4yrwftrn