In honor of finishing my first week of sign out as the “bottom line attending,” 😓 I’ve written a haiku. Behold: “New kid en bloc” Hunched over the scope Second guessing everything Saved by: “case seen with”

“I would like to be remembered as someone who used whatever talent she had to do her work to the very best of her ability." Rest In Peace to the Notorious #RBG

Vacuolar Tauopathy. Our paper in @sciencemagazine describes a novel hereditary #FrontotemporalDementia with hypomorph VCP mutation ➝ loss of tau disaggregase function. dx.doi.org/10.1126/scienc…

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau science.sciencemag.org/content/early/… Massive congratulations to Nabil Darwich and Eddie Lee for this monumental paper and achievement! (Not too shabby for Nabil Darwich ‘s #firstfirstauthorpaper 😂)

BREAKING NEWS! pennmedicine.org/news/news-rele…. This work led by our close colleague Eddie Lee demonstrates that a mutation in one of our families in the VCP gene leads to a novel form of FTLD-tau. The team named the newly discovered disease Vacuolar Tauopathy (VT). 1/n

Lauren Witzke Hi 👋🏽 proud daughter of a “third-world” boat refugee who taught herself English, worked as a grocery clerk, and got a PhD from Cambridge University in molecular biology here. SHE goes by Dr. Van Nguyen and raised 3 physicians. How about you?

Me on brain cutting this week:

Very thankFULL for a great autopsy and neuropath team. Celebrating post turkey day in the brain cutting suite.

Wu lab at Mayo is recruiting postdocs and research scientists. For those who are interested in glia and neuroimmune research, please visit neuroimmunelab.myo.edu and email [email protected].

Took a multi-month long Twitter break. What’d I miss.

Waiting for that after hour frozen the surgeon promised would come in the next 30 min

The future of #neuropathology is bright! #AANP Scholars' (hybrid) Workshop held today, St. Louis and across the US.

What every neuropathologist needs to know #neuropath2021 Dr. Louis gave us a summary of the upcoming WHO CNS classification, expected in the next few months. Adult diffuse gliomas are Marie Kondo’d: now only 3 diagnoses in this group. 😅 Summary coming up soon in SNO!

Congrats Kathryn Eschbacher, Eleni Constantopoulos and aivi like the plant (she/her), award for best neurodegen case #neuropath2021: Neuronal intranuclear inclusion disease, recently linked to NOTCH2NLC repeat expansion, aggregates from poly-gly RAN translation.

Wow. There is something oddly validating about still being able to perfuse mice after 10 yrs 😂 #sciencen00b

John Q. Trojanowski, mentor, friend. Larger than life leader in neurodegenerative disease research, probing intellect, limitless enthusiasm and energy, ever present personality. I will miss you. #RIP

Elsevier is losing editors

It is in the admission of ignorance and the admission of uncertainty that there is a hope for the continuous motion of human beings in some direction that doesn't get confined, permanently blocked, as it has so many times before in various periods in the history of man.