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theaapsjournal

@theaapsjournal

The AAPS Journal publishes novel and significant findings in the various areas of pharmaceutical sciences impacting human and veterinary therapeutics.

ID: 1220373131359150080

linkhttps://www.aaps.org/education-and-research/journals/the-aaps-journal calendar_today23-01-2020 15:50:13

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Overcoming Soluble Target Interference in Measurement of Total #Bispecific Therapeutic Antibody Concentrations | Jeongsup Shim Genentech | rdcu.be/dlqbi #AAPS American Association of Pharmaceutical Scientists #LBAs #PK #PD #SolubleTarget

Overcoming Soluble Target Interference in Measurement of Total #Bispecific Therapeutic Antibody Concentrations
| Jeongsup Shim <a href="/genentech/">Genentech</a> |
rdcu.be/dlqbi
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a>
#LBAs #PK #PD #SolubleTarget
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Evolution of Antidrug Antibody Assays During the Development of Anti-Tissue Factor Pathway Inhibitor Monoclonal Antibody Marstacimab | Steven Arkin Biorasi | rdcu.be/dlqdG #AAPS American Association of Pharmaceutical Scientists #TFPI #ADA #hemophiliaA #hemophiliaB #pharmacokinetics

Evolution of Antidrug Antibody Assays During the Development of Anti-Tissue Factor Pathway Inhibitor Monoclonal Antibody Marstacimab
| Steven Arkin <a href="/Biorasi/">Biorasi</a> |
rdcu.be/dlqdG
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a> 
#TFPI #ADA #hemophiliaA #hemophiliaB #pharmacokinetics
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Anti-drug Antibody Magnitude and Clinical Relevance Using Signal to Noise (S/N): #Bococizumab Case Study | Fred McCush Pfizer Inc. | rdcu.be/dlqf7 #AAPS American Association of Pharmaceutical Scientists #ADA #immunogenicity #SignaltoNoise

Anti-drug Antibody Magnitude and Clinical Relevance Using Signal to Noise (S/N): #Bococizumab Case Study
| Fred McCush <a href="/pfizer/">Pfizer Inc.</a> |
rdcu.be/dlqf7
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a> 
#ADA #immunogenicity #SignaltoNoise
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#Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic Therapeutics | Anne S. De Groot UGA | rdcu.be/dojce #AAPS American Association of Pharmaceutical Scientists #HCPs #immunogenicity

#Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic Therapeutics
| Anne S. De Groot <a href="/universityofga/">UGA</a> |
rdcu.be/dojce
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a>
#HCPs #immunogenicity
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Ensemble Machine Learning Approaches Based on Molecular Descriptors and Graph Convolutional Networks for Predicting the Efflux Activities of MDR1 and BCRP Transporters | Yohei Kosugi Takeda | rdcu.be/dojdG #AAPS American Association of Pharmaceutical Scientists #BCRP #MDR1 #CNSdiseases

Ensemble Machine Learning Approaches Based on Molecular Descriptors and Graph Convolutional Networks for Predicting the Efflux Activities of MDR1 and BCRP Transporters
| Yohei Kosugi <a href="/TakedaPharma/">Takeda</a> | 
rdcu.be/dojdG
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a>
#BCRP #MDR1 #CNSdiseases
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Phase-appropriate Application of Process Analytical Technology for Early Pharmaceutical Development of Oral Solid Dosage Forms—the Case Study of Uniformity Screening of Dosage Units and Blends | Sayyeda Zeenat Razvi Patheon | rdcu.be/dojhc #AAPS American Association of Pharmaceutical Scientists #PAT #TRS

Phase-appropriate Application of Process Analytical Technology for Early Pharmaceutical Development of Oral Solid Dosage Forms—the Case Study of Uniformity Screening of Dosage Units and Blends
| Sayyeda Zeenat Razvi <a href="/Patheon/">Patheon</a> |  
rdcu.be/dojhc
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a> 
#PAT #TRS
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Addressing Domain Specificity in the Development of a Cell-Based Binding Assay for the Detection of Neutralizing Antibodies Against a CD47xPD-L1 Bispecific Antibody | Michael Luong Pfizer Inc. | rdcu.be/doljj #AAPS American Association of Pharmaceutical Scientists #NAb #BEAD

Addressing Domain Specificity in the Development of a Cell-Based Binding Assay for the Detection of Neutralizing Antibodies Against a CD47xPD-L1 Bispecific Antibody
| Michael Luong <a href="/pfizer/">Pfizer Inc.</a> | 
rdcu.be/doljj
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a>
#NAb #BEAD
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Applications of Modeling and Simulation Approaches in Support of Drug Product Development of Oral Dosage Forms and Locally Acting Drug Products: a Symposium Summary | Eleftheria Tsakalozou @US_FDAJaiwoo | rdcu.be/drATV #AAPS American Association of Pharmaceutical Scientists #IVIVC #PBPK #foodeffect

Applications of Modeling and Simulation Approaches in Support of Drug Product Development of Oral Dosage Forms and Locally Acting Drug Products: a Symposium Summary
| Eleftheria Tsakalozou @US_FDAJaiwoo |
rdcu.be/drATV  
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a>
#IVIVC #PBPK #foodeffect
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Role of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development | Maxime Siemons @JanssenBelgium | rdcu.be/drAWz #AAPS American Association of Pharmaceutical Scientists #MIDD #IVIVCs #LAI

Role of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development
| Maxime Siemons @JanssenBelgium | 
rdcu.be/drAWz
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a>
#MIDD #IVIVCs #LAI
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Tuning the Emulsion Properties Influences the Size of Poly(Caprolactone) Particles for Drug Delivery Applications | Brittany E. Givens UK Engineering | rdcu.be/drAXN #AAPS American Association of Pharmaceutical Scientists #PCL #Microparticles #Microspheres #Nanoparticles

Tuning the Emulsion Properties Influences the Size of Poly(Caprolactone) Particles for Drug Delivery Applications
| Brittany E. Givens <a href="/ukyengineering/">UK Engineering</a> |   
rdcu.be/drAXN 
#AAPS <a href="/AAPSComms/">American Association of Pharmaceutical Scientists</a>
#PCL #Microparticles #Microspheres #Nanoparticles