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🚨Today in nature, we show that mRNA mis-splicing creates clonal public neoantigens in solid cancers. An amazing collaboration between UCSF Helen Diller Family Comprehensive Cancer Ctr and Memorial Sloan Kettering Cancer Center driven by Darwin Kwok and co-led by Hideho Okada, Joe Costello and Klebanoff_Lab. nature.com/articles/s4158…

#Immunology out now Science Magazine After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/lCPsea3 By Jobinet al.

Very cool study Kevin (Yan-Ting) Chen Santosh Vardhana !!

Enormously grateful to Pershing Square Sohn Cancer Research Alliance for their support which will allow us to embark on studies of Thetis cells in colorectal cancer, a wonderful collaboration with Karuna Ganesh Lab!