🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

When drug resistance mutations develop in the clinic, it is devastating. Yet, these same mutations are often important tools in the lab. In a review out today Nature Chemical Biology, we survey the many groundbreaking discoveries made possible by resistance mutations. nature.com/articles/s4158…

Bob and I wrote a review on Polycomb. We discussed how the conserved Polycomb mechanism is repurposed in various developmental contexts, and what we have learned from this diversity. Many thanks to everyone for valuable comments along the way!

June Huh, who was awarded the Fields Medal this morning, took an unconventional path into the world of mathematics. I had the privilege of profiling him for Quanta Magazine: quantamagazine.org/june-huh-high-…

Did you know there are lots of similarities between the innate immune systems of animals/plants and the phage defense systems in bacteria? Check out our new study by the amazing trio Alex (Linyi) Gao, Max Wilkinson, and Jonathan Strecker. Congratulations! science.org/doi/abs/10.112….

So exciting!

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Physics to Alain Aspect, John F. Clauser and Anton Zeilinger.

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

Tardigrades can live 30 years w/o food or water. 🐻 And now there's a genetic toolkit to engineer them! It includes: - Promoters for tissue-specific expression. - A plasmid, called TardiVec. More water bear projects, please. pnas.org/doi/10.1073/pn…

Excited to share that our paper discovering drug addiction to PRC2 inhibitors is out at Nature Chemical Biology! Congrats to my co-lead author, Hui Si Kwok, and the Liau Lab PRC2 team including Allison Siegenfeld, Julia Morriss, @proteinnns, Stephen Kissler and Brian Liau! We did it!

CBX2 paper now published in G&D. Main conclusions: 1) CBX2 (cPRC1) function is specific to committed progenitors, not stem cells 2) Histone modification (H3K27me3) alone is not sufficient - proteins binding them are also critical for cell fate. pubmed.ncbi.nlm.nih.gov/37553262/

First post, first preprint from my postdoc in the Kingston Lab: Tuning condensates - How Polycomb Repressive Complex 1 subunit combinations determine condensate initiation, morphology, stability, and dynamics biorxiv.org/content/10.110…

Thank you Molecular Cell for this terrific #Spotlight piece written about our new work published last month in Cell Cell Press! Congrats again to Ajinkya Patil Amy Strom brangwynnelab @PappulabWashU Kadoch Lab and all coauthors!

👇🏽 First CRISPR-based medicine approved Amazing new option for patients with sickle-cell disease & b-thal MHRA authorises world-first gene therapy that aims to cure sickle-cell disease and transfusion-dependent β-thalassemia - GOV.UK gov.uk/government/new…

A truly historic moment, first CRISPR therapy approved! Key ingredients: astute clinical observation on HbF and SS (Janet Watson ca 1948), basic developmental biology, human genetics including GWAS for target ID, and of course CRISPR gov.uk/government/new…

In a major milestone for science, for medicine, and for patients, the world’s first CRISPR drug has been approved in the UK. “A new treatment for sickle-cell disease and transfusion-dependent β-thalassemia has been authorised by the Medicines and Healthcare products Regulatory

Very excited to see our work on PRC1 and chromatin condensation online Molecular Cell cell.com/molecular-cell… I am grateful to have worked with and learned from Sharon and Theresa Oei during this project! Many thanks to Radhika and Bob for their guidance and support throughout!

We are recruiting a postbac research technician to join us! We will work together to set up the new lab and do exciting experiments on chromatin factors critical for transcriptional fidelity. Please RT. Job post: cornell.wd1.myworkdayjobs.com/en-US/CornellC…

I am excited to share my first project in @jwadeharperlab for feedback. We used spatiotemporal proteomics (1) to describe how cells respond to NLRP3 agonists and (2) to profile the proximal proteome as NLRP3 trafficks to the site of inflammasome nucleation harperlab.pubpub.org/pub/nlrp3/

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…