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When Einthoven introduced the ECG to the world, he uniquely labeled its parts PQRST, inspired by mathematicians who used Ps & Qs in coordinates. Yet, he believed there was more to find, so he started in the alphabet's middle, leaving room for new discoveries on both sides. 1/n

Excited to share our preprint led by Sarah Urbut & with Akl Fahed. For pts without CAD, the relative importance of risk factors changes over time. As a result, a CAD polygenic risk score is much better earlier in life & recovers the poorer performance of clinical risk scores

Pradeep Natarajan Sarah Urbut Broad Institute Mass General Heart MGH Cardiology Fellows MGH Cardiovascular Research Center CGM at MGH Harvard Medical School @MGH_RI Very cool integration of genetics and clinical measurements, leveraging massive population based outcomes datasets in Framingham and the UK by Pradeep Natarajan and friends. Crystal ball for CV outcomes, crushing how “healthy blue” is halved from 50 to 70.

Pumped for this hour of amazing content led by current and former early career investigators ⁦Mass General Heart⁩ ⁦Broad Institute⁩ at #AHA2023. Check it out later today!! ⁦James Pirruccello⁩ ⁦Joel Rämö⁩ ⁦Sarah Urbut⁩ ⁦Lu-Chen Weng⁩

Congratulations to Dr Sarah Urbut ⁦Sarah Urbut⁩ for a phenomenal presentation on time-dependent risk assessment at the Elizabeth Barrett Connor YIA in Epi/Prevention at #aha23. ⁦MGH Cardiology Fellows⁩ ⁦Doreen DeFaria Yeh, MD⁩ ⁦⁦Pradeep Natarajan⁩ ⁦Patrick Ellinor⁩

Join us Wed 11/15 12-1p in Simches 3.110 to hear exciting new unpublished work from Aniruddh Patel & Satoshi Koyama for the CGM at MGH @MGH_RI weekly seminar, and also from Sarah Urbut & Yixuan He 1-2p in Simches 2 Garrod/Mendel during the CGM at MGH trainee session

Congrats Sarah Urbut for being a UK Biobank Early Career Researcher of the Year Runner-Up!! #UKBSC23 Broad Institute MassGeneral News

So excited to share our work using multi-state modeling to predict dynamic risk of CAD over the lifetime. Thanks to amazing team and mentorship Pradeep Natarajan Sasha Gusev Giovanni Parmigiani MGH Cardiology Fellows !

Thrilled to share our latest preprint!📜 A major project I’ve led during my PhD, examining how genetic factors influence weight loss outcomes from GLP1 receptor agonists and bariatric surgery across 9 biobanks and 10,960 individuals. 📷#Genetics #obesity #MedicalResearch

A massive congratulations to Sarah Urbut Sarah Urbut on a stellar presentation and a well deserved win in an incredible cohort for the ECC GPM Early Career Investigator Award Prize…

Delighted to share our study by Sarah Urbut with Akl Fahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events ahajournals.org/doi/10.1161/CI… Circulation: Genomic and Precision Medicine

📣 The recording of "A Practical Primer on Bayesian Statistics" by Sarah Urbut is now available: youtube.com/watch?v=jcFSuk… This talk is part of Broad Institute's MPG Primer series. For more info, check out broad.io/MPGPrimer

The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! Sarah Urbut's talk to Broad Institute BroadMPG : A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFSuk… We are incredibly lucky to have her

HUGE congrats to graduating MGH Cardiology Fellows Sarah Urbut Sumeet Khetarpal, both 🌟 preventive cardiologist-scientists, for receiving Burroughs Wellcome Fund Career Awards for Medical Scientists!! We are thrilled that Sarah Urbut will stay with us Mass General Heart Broad Institute & also