🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Lobbying: Of the 66 signatories of the anti-Stonewall letter, 2/3 came from 5 UCL departments (out of 100+) containing prolific members of the Women's Liberation SIG, a 'Gender Critical Feminist' group. These signatories alone made up over 1/3 of anti-Stonewall voters.

Our review of the structures of VPS13, ATG2, hobbit and many other lipid transfer proteins that bridge between organelles at a #membranecontactsite is out Thanks to Sarah Neuman and Arash Bashirullah for such a fruitful collaboration. Thread contains some of the figures.

For some years we've known that lipids flow between organelles on static bridges (VPS13, ATG2 …) AlphaFold allowed us to define a Repeating Beta Groove (RBG) domain in all the bridges x.com/hobbitflygirl/… Now here's new detail showing how RBG superfamily bridges might work

Since our new PM is not going to #cop27egypt, Keir Starmer should go - that would send a very strong message on leadership.

Our 6-way collaboration is out, led by Schuldiner lab Weizmann Institute, Liz Conibear lab University of British Columbia & Chris Stefan UCL Laboratory for Molecular Cell Biology. Also Vanina Zaremberg Biological Sciences UofC & Robert Ernst SaarlandU We found lots of new contact site proteins, many of which transfer lipid elifesciences.org/articles/74602

Elife is moving forward but its claim to be “relinquishing role of gatekeeper” applies only to removing gate #2. Elife will still keep gate #1: “we do not have the capacity to review every preprint submitted to us”. Deciding what to review is now uniquely important... & secret!

Our lab has a new preprint out on how LAM proteins self-organise into puncta. This turns out to NOT positively affect function ... rather the opposite. biorxiv.org/content/10.110… +We collaborated with Wanda Kukulski to idenitfy the ER architecture at LAM+ puncta: it's unremakrable.

Excellent new paper from the lab of Sabrina Buttner (& collaborators incl. me!) showing LDO proteins bridge from lipid droplets to the yeast vacuole to allow lipophagy during starvation. Could the animal LDO-ologue promethin (=LDAF) act similarly? it has ~30aa disordered tail.

Yaoyang Zhong, PhD student in my lab, & I have a new News and Views in contactctc about the discovery by Karin Reinisch's team (Yale) that the senescence domain in Spartin is a lipid transfer protein doi.org/10.1177/251525… The original work is in PNAS: pnas.org/doi/10.1073/pn…

Also, quite coincidentally to me working at UCL Institute of Ophthalmology, a mutation in CLCC1 causes a rare autosomal recessive #Retinitis (RP32) ncbi.nlm.nih.gov/pmc/articles/P… Is the molecular basis of that blinding disorder related to nuclear pore complex insertion? Or another nuclear envelope function?