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Thanks Dr Kate Weeks ACvA Journal of Molecular and Cellular Cardiology for the invite & support - looking forward to the session!

1/6 Thrilled to share the first project from my PhD in the The Arany lab out today in @ScienceMag, co-led by Cholsoon Jang (while @ Rabinowitz Lab) and w/ Dr. David Frankel and Dr. Matthew Hyman of the EP section Penn Medicine. #cardiotwitter science.sciencemag.org/content/370/65…

Yes - he wrote to me and sent me this article a few weeks ago too! He really did discover the shuttle 60 yrs ago. I sent him the recent NAD transport papers from @nora_kory David M. Sabatini Baur Lab Lulu Cambronne. He seemed happy to see this is a major area of research in 2020.

Attention all #mitochondriacs Check out our latest work in Scientific Reports where we describe a method for quantifying mitochondrial content and intrinsic OXPHOS efficiency using mass spectrometry, respirometry and fluorescence nature.com/articles/s4159…. See 👇 for details. 1/

Online now! Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice dlvr.it/RkNjRV

Excited to finally share my postdoctoral work and latest manuscript from the @EricVerdin Lab and Buck Institute exploring how senescent cells promote tissue #NAD decline during ageing via the activation of CD38+ macrophages. nature.com/articles/s4225…

#NatMetabPicks | Reporting in @nature, Xiaolu Cambronne (UT Austin), Joe Baur & Tim Luongo (Penn) identify the mitochondrial NAD+ transporter nature.com/articles/s4158…

The RECOVERY Data Monitoring Committee reviewed data on patients randomised to convalescent plasma vs. usual care. The preliminary analysis based on 10,406 randomised patients with 1873 reported deaths shows no significant difference in the primary endpoint of 28-day mortality.

Mitochondria is the powerhouse of the cell.

D-day alert: Nature Cardiovascular Research site is now live! nature.com/natcardiovascr… To all my followers who have cardiovascular and blood biology @❤️ and 'in their veins', please follow us Nature Cardiovascular Research We're open for submissions in mid-April!

We had a blast writing this mini-review on the recent discovery of the mito-NAD transporter in mammalian cells, & what it could mean for the broader field of NAD biology. Alex Bott Yeyun Ouyang Giulio Superti-Furga @KoryLab Tim Luongo Enrico Girardi Trends in Biochemical Sciences authors.elsevier.com/a/1ccL33S6GfF7…

Our new paper is out online! We uncovered a surprising ability of the adult heart to withstand defects to the mtDNA maintenance machinery. The developed vs. developing heart respond very differently to mito dysfunction. #mitochondria #heart journals.physiology.org/doi/abs/10.115…

Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting‐ and ghrelin‐mediated food intake faseb.onlinelibrary.wiley.com/doi/10.1096/fj…

We are excited to share the first paper from our lab Nature Metabolism. We discovered that mitochondrial NADP+ is essential to enable proline synthesis and reveal the first example of mammalian proline auxotrophy nature.com/articles/s4225…. 1/12

Congrats to Sarmistha Murkherjee for her recent study revealing that SIRT3 is required for liver regeneration and that the benefits of boosting #NAD are independent of sirtuins. insight.jci.org/articles/view/…

Excited to share our recent work spearheaded by Anna Garcia Whitlock, MD, PhD that show an important role for hepatic FOXO transcription factors in driving stress-induced hyperglycemia and insulin resistance in mouse models of trauma PennSurgery Penn IDOM Molecular Metabolism sciencedirect.com/science/articl…

In the failing heart, short chain fatty acids (SCFA) are more readily oxidized than ketones & represent an unexplored source of energy production. Read more: ow.ly/moXN50EEwPH #AHAJournals Doug Lewandowski

What a journey! I can finally share with the world the work I’ve been able to accomplish during the time of my postdoctoral training. 🧵 authors.elsevier.com/c/1doI78YyDffJ…

Therapeutic Discovery at StrideBio is hiring! Apply if you are interested in developing gene therapies for cardiovascular disease. stridebio.applicantpool.com/jobs/591257.ht…

Our new study describing a "potential" mitochondrial glutathione transporter (SLC25A39 and 40). Congrats to all of my amazing lab members and collaborators involved in this work for the last 4 years. Rockefeller University nature @TriIMDPhD nature.com/articles/s4158…