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Delighted to share our collaborative efforts exploring the basis of leptin resistance in obesity. We address the long-standing enigma that obese humans and animals exhibit elevated leptin levels and show little response to exogenous leptin therapy. biorxiv.org/content/10.110…

#paxunplugged #geneticcodegame #boardgames #womeninSTEM #boardgamedesign

play testing the Genetic Code Game with 4 teens to CRISPR out all the mutations for #PAXunplugged2023 #stem #womenboardgamedesigners #scienceboardgames #stemboardgames #geneticcodegame #womeninscience #PAXunplugged

I'm honored and very excited to be presenting two of my games at the PAX Rising Showcase at #PAXUnplugged. The two games are: The Genetic Code, a collaboration with Kristina, and Floristry with @deg23deg. Come check out my other prototypes as well at the The Unpublished Games Network room 201B.

Bowen’s Thesis Defense!!! 😱😱😱 rockefeller.edu/events-and-lec…

demoing the #geneticcodegame at #PAXUnplugged #paxrisingshowcase

made some new spaceship prototypes for a new boardgame called Space-Time based on chapter 3 from #theElegantUniverse by #briangreene

BREAKING: Man eats a full jar of cheeseballs in Union Square Park today. For the last 2 weeks, his posters promoting the challenge were spotted across the city. Today he made history. Cheeseballman427’s identity is unknown but he’s a local hero to many NYC patrons. We expect

Lots of bioRxiv citations in talks at the Cold Spring Harbor Laboratory Symposium (like many meetings), but amazing to see it feature in Jeff Friedman’s public lecture to the local community 😀

Who did this lolololololol

lol

A new study from the #FriedmanLab in Cell Metabolism identifies a neural mechanism involved in leptin resistance—and, crucially, a way to reverse it in mice using a well-known drug. #RockefellerScience rockefeller.edu/news/37433-res…

On this #WorldObesityDay, we bring you this Special Issue on Obesity, highlighting the complexities of this disease and systemic challenges we must overcome to combat it. cell.com/cell-metabolis…

A cellular and molecular basis of leptin resistance: Cell Metabolism cell.com/cell-metabolis… Bowen Tan Alexandre Moura Assis

30 years after discovering leptin, Jeff Friedman's lab has located a neural mechanism in obese mice that helps explain leptin resistance. In this Q&A, he discusses how dysregulated leptin leads us to put on pounds, new treatments for obesity, and more: rockefeller.edu/news/37460-a-s…

A prelude: 1. Humans with obesity have high endogenous leptin levels. 2. Exogenous leptin is insufficient to reduce weight in these individuals. 3. Leptin resistance is thought to involve a putative block in the brain. What are the biological substrates of this putative block?

Rapamycin Restores Leptin Sensitivity and Leads to Fat Loss in Obese Mice Rockefeller University Friedman Lab researchers study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications hubs.li/Q039pSQ60

White House Evacuated After Trans Alarm Goes Off theonion.com/white-house-ev…

youtu.be/kkt-s39bwWY