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Our latest study - psilocybin evokes structural neural plasticity, and we wanted to know how this maps onto pyramidal cell type-specific circuits to produce behavioral effects. 🍄🔬🧠 Link to bioRxiv: biorxiv.org/content/10.110… Led by Ling-Xiao Shao and Clara Liao.

Happy to share the lab’s latest research tagging psychedelic-activated neurons in mice. See the post below from first author Jessie Muir for a tweeprint on the work. Thanks to wonderful collaborators Olson Lab Lin Tian, PhD and to our reviewers/editor! science.org/doi/10.1126/sc…

Excited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture. sciencedirect.com/science/articl…

Excited to share new study from the lab, work led by John and grateful for all the collaborators who made this possible including ChangLabUCSF UC Santa Cruz Genomics Institute

Check out our minireview on DA sensors and how they benefited neuroscience: authors.elsevier.com/a/1k6hE8MqMiqW… Great teamwork of my students and postdoc Xuehan Zacharoula and Paul

My student Julie's pre-print on generalized cell phenotyping for spatial proteomics is finally out! Julie's work integrates large-scale image labeling and language-informed vision models to enable accurate and general cell phenotyping. biorxiv.org/content/10.110…

Online now on biorxiv: our new voltage indicator engineered for red 2P optical recordings, 2Photron. Only possible thanks to great collaborators Eric Schreiter,Dieudonné lab @[email protected],Kaspar Podgorski, and others! biorxiv.org/content/10.110…

There are many nuances regarding the structural neural plasticity associated with antidepressant drugs. 💊🧠 We share our thoughts here in a Nature Rev Neurosci article, led by Clara Liao and included co-authors from Conor Liston’s lab at Weill Cornell Medicine Psychiatry nature.com/articles/s4158…

In collaboration with Reuben Saunders, Jonathan Weissman's Lab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

1/✨ New paper in #eNeuro! How do dominance behaviors vary across mouse strains? Turns out, it’s not one-size-fits-all! Comparing CD1 & C57 mice, we found strain-specific behaviors that could change how we study social hierarchy in the lab🧵 Paper here: tinyurl.com/bdeuf6s9

qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification. biorxiv.org/content/10.110…

Congrats to Run Zhang on a fantastic thesis defense! His thesis developed activity-dependent proximity labeling tools for activated neurons—displaying a mastery of protein engineering, optimization, & characterization of enzyme modules. We will miss you in the lab, Run!

Our latest work led by Clara Liao is a collaboration with the other Kwan lab Ken Kwan We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬 biorxiv.org/content/10.110…

Nice full length story about one of the pioneering and inspiring scientists of our generation.

Registration for the 2025 Max Planck Florida Institute for Neuroscience Neurotechniques Course closes this Wednesday! Co-directed by Ryohei りょうへー & Denise J. Cai, Ph.D. and led by an amazing team of experts, this hands-on course is a great opportunity to learn cutting-edge methods in neuroscience 🔬🧠

Our lab at UC Davis has a project opening through this excellent program, check it out if you're a neuroscience-interested undergraduate in the area 👇

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🐁 Led by Ling-Xiao Shao and Clara Liao Funded by NIH National Institute of Mental Health (NIMH) 📄Read in nature - nature.com/articles/s4158… 1/12

I had a great time at the Max Planck Florida Institute for Neuroscience Advanced Neurotechniques Course this week, teaching a mini2P module w/ Lin Tian, PhD, Jacob Roshgadol & J Kerr! It’s been a while since I’ve stayed up that late analyzing data 😅 So impressed with our amazing students & the beautiful MPFI campus 🤩

Excited to share our new study: "Cold memories control whole-body thermoregulatory responses" by Andrea Muñoz Zamora, Aaron Douglas & team at Trinity College Dublin, in collaboration with Lydia Lynch & Christine Ann Denny Ryan Lab nature nature.com/articles/s4158…

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & for myself, expanding my inpatient neuropsychiatry work to the service