
Tokuriki lab
@tokuriki_lab
Scientist @ubcmsl, Protein Evolution and Engineering.
ID: 1387644649175601152
https://tokurikilab.msl.ubc.ca/ 29-04-2021 05:47:32
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605 Followers
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Karol Buda, Charlotte Miton with colleagues in the Tokuriki lab perform statistical analyses to demonstrate that epistasis is highly pervasive in adaptive evolutionary trajectories of enzymes. #epistasis, #proteinevolution nature.com/articles/s4146…


Mark your calendars! SynBio6.0 is coming to University of British Columbia in Vancouver on May 16-17 this year! We have an incredible lineup of keynote speakers Rebecca Shapiro Ron Weiss @LeopoldParts Pulin Li. Don't miss out--submit your abstract and register now!👉de-boer-lab.github.io/synbio6-0.gith…


Are you interested how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. Nature Catalysis nature.com/articles/s4192…

Happy to share that our latest paper led by Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️🌈 and Adrian Bunzel 🇪🇺🇨🇭🇩🇪🏳️🌈 is out Nature Catalysis. If you like protein evolution and epistasis, this paper will give you interesting insights; Shifting the rate-limiting step can cause strong epistasis. nature.com/articles/s4192…


Congrats to Dan Kozome, who published today in Nature Communications part of his PhD work OIST 🥳!!! Pls check it here rdcu.be/dELQk and in the following:

Our exciting collaboration with the great Tokuriki lab on the biophysical basis for the malleability of trait correlation in single proteins (YFP and VIM2 metallo-β-lactamase) and on short evolutionary time scales. nature.com/articles/s4146…


Just out in Nature Communications our findings on the metabolic interaction between two non-consecutive enzymes (ICD and MDH) involved in the TCA cycle! A amazing collaborations with Bershtein group Ben-Gurion University of the Negev and @Serohijos group MontrealUniversity OIST nature.com/articles/s4146…


Our latest manuscript "Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning" is out Nature Communications It is a great collaboration with Francesco Zamponi and Martin Weigt! nature.com/articles/s4146…


I am very excited to share that our paper led by Ayşe Nisan Erdoğan, Pouria Dasmeh, Adrian Serohijos is out Nature Communications. It touches key dynamics to understand protein evolution"Neutral Drift" and "Phenotypic Variation" during enzyme/protein evolution. nature.com/articles/s4146…

Ending 2024 with the publication of my first first-author paper titled "Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype" on Nature Communications!



Our new perspective paper, led by Sevan Gholipour and Dongkyu Lee, is out Biochemistry. We discussed molecular evolution and origins of antibiotic resistance genes" It is interesting to think how ARG evolved against natural vs synthetic antibiotics. pubs.acs.org/doi/10.1021/ac…