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Karol Buda, Charlotte Miton with colleagues in the Tokuriki lab perform statistical analyses to demonstrate that epistasis is highly pervasive in adaptive evolutionary trajectories of enzymes. #epistasis, #proteinevolution nature.com/articles/s4146…

Mark your calendars! SynBio6.0 is coming to University of British Columbia in Vancouver on May 16-17 this year! We have an incredible lineup of keynote speakers Rebecca Shapiro Ron Weiss @LeopoldParts Pulin Li. Don't miss out--submit your abstract and register now!👉de-boer-lab.github.io/synbio6-0.gith…

Are you interested how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. Nature Catalysis nature.com/articles/s4192…

Happy to share that our latest paper led by Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈 and Adrian Bunzel 🇪🇺🇨🇭🇩🇪🏳️‍🌈 is out Nature Catalysis. If you like protein evolution and epistasis, this paper will give you interesting insights; Shifting the rate-limiting step can cause strong epistasis. nature.com/articles/s4192…

Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes | PNAS pnas.org/doi/10.1073/pn…

Congrats to Dan Kozome, who published today in Nature Communications part of his PhD work OIST 🥳!!! Pls check it here rdcu.be/dELQk and in the following:

Our exciting collaboration with the great Tokuriki lab on the biophysical basis for the malleability of trait correlation in single proteins (YFP and VIM2 metallo-β-lactamase) and on short evolutionary time scales. nature.com/articles/s4146…

Congratulations to the 2024 Astell Award recipients, Ayşe Erdogan and Jenna Goeres! 👏 Join us for the award presentation at the upcoming MBIM, BMB, and CPS EDI seminar! 📍 May 13, 2:30pm, LSC 3 biochem.ubc.ca/equity-diversi…

Just out in Nature Communications our findings on the metabolic interaction between two non-consecutive enzymes (ICD and MDH) involved in the TCA cycle! A amazing collaborations with Bershtein group Ben-Gurion University of the Negev and @Serohijos group MontrealUniversity OIST nature.com/articles/s4146…

📢 Thrilled to announce our latest research in Cell! We've created a global ‘superbug map’ for a critically antibiotic-resistant bacterium to inform #phagetherapy 🧵1/11 cell.com/cell/fulltext/…

Our latest manuscript "Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning" is out Nature Communications It is a great collaboration with Francesco Zamponi and Martin Weigt! nature.com/articles/s4146…

This account beat me to it… a very talented HFSP postdoc with me (John Chen no twitter) has developed a hierarchical clustering method that overcomes many of the issues with traditional seq similarity networks.

I am very excited to share that our paper led by Ayşe Nisan Erdoğan, Pouria Dasmeh, Adrian Serohijos is out Nature Communications. It touches key dynamics to understand protein evolution"Neutral Drift" and "Phenotypic Variation" during enzyme/protein evolution. nature.com/articles/s4146…

Ending 2024 with the publication of my first first-author paper titled "Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype" on Nature Communications!

Excited to share a new preprint! We've discovered repeated evolution of protein 3D structure in recurrently emerged bacterial ALDH-ADH fusion enzymes. Repeatability of protein structural evolution following convergent gene fusions biorxiv.org/content/10.110…

世界を変える、独創を讃える。『第2回 神戸賞』の受賞者が決定！ prtimes.jp/main/html/rd/p…

Our new perspective paper, led by Sevan Gholipour and Dongkyu Lee, is out Biochemistry. We discussed molecular evolution and origins of antibiotic resistance genes" It is interesting to think how ARG evolved against natural vs synthetic antibiotics. pubs.acs.org/doi/10.1021/ac…