Tokuriki lab (@tokuriki_lab) 's Twitter Profile
Tokuriki lab

@tokuriki_lab

Scientist @ubcmsl, Protein Evolution and Engineering.

ID: 1387644649175601152

linkhttps://tokurikilab.msl.ubc.ca/ calendar_today29-04-2021 05:47:32

163 Tweet

605 Followers

185 Following

Nature Communications (@naturecomms) 's Twitter Profile Photo

Karol Buda, Charlotte Miton with colleagues in the Tokuriki lab perform statistical analyses to demonstrate that epistasis is highly pervasive in adaptive evolutionary trajectories of enzymes. #epistasis, #proteinevolution nature.com/articles/s4146…

<a href="/_karolbuda/">Karol Buda</a>, <a href="/CharlotteMiton/">Charlotte Miton</a> with colleagues in the <a href="/tokuriki_lab/">Tokuriki lab</a> perform statistical analyses to demonstrate that epistasis is highly pervasive in adaptive evolutionary trajectories of enzymes. #epistasis, #proteinevolution

nature.com/articles/s4146…
Nozomu Yachie (@nzmyachie) 's Twitter Profile Photo

Mark your calendars! SynBio6.0 is coming to University of British Columbia in Vancouver on May 16-17 this year! We have an incredible lineup of keynote speakers Rebecca Shapiro Ron Weiss @LeopoldParts Pulin Li. Don't miss out--submit your abstract and register now!👉de-boer-lab.github.io/synbio6-0.gith…

Mark your calendars! SynBio6.0 is coming to <a href="/UBC/">University of British Columbia</a> in Vancouver on May 16-17 this year! We have an incredible lineup of keynote speakers <a href="/ShapiroRebecca/">Rebecca Shapiro</a> <a href="/Ron_Weiss_MIT/">Ron Weiss</a> @LeopoldParts <a href="/Pulin_Li/">Pulin Li</a>. Don't miss out--submit your abstract and register now!👉de-boer-lab.github.io/synbio6-0.gith…
Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈 (@chrfrohlich) 's Twitter Profile Photo

Are you interested how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. Nature Catalysis nature.com/articles/s4192…

Tokuriki lab (@tokuriki_lab) 's Twitter Profile Photo

Happy to share that our latest paper led by Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈 and Adrian Bunzel 🇪🇺🇨🇭🇩🇪🏳️‍🌈 is out Nature Catalysis. If you like protein evolution and epistasis, this paper will give you interesting insights; Shifting the rate-limiting step can cause strong epistasis. nature.com/articles/s4192…

Mikael Elias (@elias_mikael) 's Twitter Profile Photo

Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes | PNAS pnas.org/doi/10.1073/pn…

Pouria Dasmeh (@pouriadasmeh) 's Twitter Profile Photo

Our exciting collaboration with the great Tokuriki lab on the biophysical basis for the malleability of trait correlation in single proteins (YFP and VIM2 metallo-β-lactamase) and on short evolutionary time scales. nature.com/articles/s4146…

UBC Biochemistry & Molecular Biology (@ubcbiochemistry) 's Twitter Profile Photo

Congratulations to the 2024 Astell Award recipients, Ayşe Erdogan and Jenna Goeres! 👏 Join us for the award presentation at the upcoming MBIM, BMB, and CPS EDI seminar! 📍 May 13, 2:30pm, LSC 3 biochem.ubc.ca/equity-diversi…

Congratulations to the 2024 Astell Award recipients, Ayşe Erdogan and Jenna Goeres! 👏

Join us for the award presentation at the upcoming MBIM, BMB, and CPS EDI seminar!

📍 May 13, 2:30pm, LSC 3 
biochem.ubc.ca/equity-diversi…
Paola Laurino (@paolalaurino) 's Twitter Profile Photo

Just out in Nature Communications our findings on the metabolic interaction between two non-consecutive enzymes (ICD and MDH) involved in the TCA cycle! A amazing collaborations with Bershtein group Ben-Gurion University of the Negev and @Serohijos group MontrealUniversity OIST nature.com/articles/s4146…

BalintKintsesLab (@kintseslab) 's Twitter Profile Photo

📢 Thrilled to announce our latest research in Cell! We've created a global ‘superbug map’ for a critically antibiotic-resistant bacterium to inform #phagetherapy 🧵1/11 cell.com/cell/fulltext/…

📢 Thrilled to announce our latest research in <a href="/CellCellPress/">Cell</a>! We've created a global ‘superbug map’ for a critically antibiotic-resistant bacterium to inform #phagetherapy 🧵1/11 cell.com/cell/fulltext/…
Tokuriki lab (@tokuriki_lab) 's Twitter Profile Photo

Our latest manuscript "Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning" is out Nature Communications It is a great collaboration with Francesco Zamponi and Martin Weigt! nature.com/articles/s4146…

Colin Jackson (@jackson_lab) 's Twitter Profile Photo

This account beat me to it… a very talented HFSP postdoc with me (John Chen no twitter) has developed a hierarchical clustering method that overcomes many of the issues with traditional seq similarity networks.

Tokuriki lab (@tokuriki_lab) 's Twitter Profile Photo

I am very excited to share that our paper led by Ayşe Nisan Erdoğan, Pouria Dasmeh, Adrian Serohijos is out Nature Communications. It touches key dynamics to understand protein evolution"Neutral Drift" and "Phenotypic Variation" during enzyme/protein evolution. nature.com/articles/s4146…

Ayşe Nisan Erdoğan (@erdogananisan) 's Twitter Profile Photo

Ending 2024 with the publication of my first first-author paper titled "Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype" on Nature Communications!

Naoki Konno (@utnk1) 's Twitter Profile Photo

Excited to share a new preprint! We've discovered repeated evolution of protein 3D structure in recurrently emerged bacterial ALDH-ADH fusion enzymes. Repeatability of protein structural evolution following convergent gene fusions biorxiv.org/content/10.110…

Tokuriki lab (@tokuriki_lab) 's Twitter Profile Photo

Our new perspective paper, led by Sevan Gholipour and Dongkyu Lee, is out Biochemistry. We discussed molecular evolution and origins of antibiotic resistance genes" It is interesting to think how ARG evolved against natural vs synthetic antibiotics. pubs.acs.org/doi/10.1021/ac…